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A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease
A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease
- Source :
- Translational Stroke Research, Stringer, M S, Lee, H, Huuskonen, M T, MacIntosh, B J, Brown, R, Montagne, A, Atwi, S, Ramirez, J, Jansen, M A, Marshall, I, Black, S E, Zlokovic, B V, Benveniste, H & Wardlaw, J M 2021, ' A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease ', Translational Stroke Research, vol. 12, no. 1, pp. 15-30 . https://doi.org/10.1007/s12975-020-00843-8
- Publication Year :
- 2020
-
Abstract
- Cerebral small vessel disease (SVD) is a major health burden, yet the pathophysiology remains poorly understood with no effective treatment. Since much of SVD develops silently and insidiously, non-invasive neuroimaging such as MRI is fundamental to detecting and understanding SVD in humans. Several relevant SVD rodent models are established for which MRI can monitor in vivo changes over time prior to histological examination. Here, we critically review the MRI methods pertaining to salient rodent models and evaluate synergies with human SVD MRI methods. We found few relevant publications, but argue there is considerable scope for greater use of MRI in rodent models, and opportunities for harmonisation of the rodent-human methods to increase the translational potential of models to understand SVD in humans. We summarise current MR techniques used in SVD research, provide recommendations and examples and highlight practicalities for use of MRI SVD imaging protocols in pre-selected, relevant rodent models. Electronic supplementary material The online version of this article (10.1007/s12975-020-00843-8) contains supplementary material, which is available to authorised users.
- Subjects :
- Rodentia
Brain imaging
Disease
Review Article
030218 nuclear medicine & medical imaging
Translational Research, Biomedical
03 medical and health sciences
Lacunar infarcts
0302 clinical medicine
Neuroimaging
medicine
Effective treatment
Animals
Humans
Histological examination
medicine.diagnostic_test
business.industry
General Neuroscience
Magnetic resonance imaging
Systematic reviews
Magnetic Resonance Imaging
3. Good health
Small vessel disease
Lacunar Infarcts
Cerebrovascular Disorders
Disease Models, Animal
Microvessels
Dementia
Neurology (clinical)
Small vessel
Cardiology and Cardiovascular Medicine
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1868601X
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Translational stroke research
- Accession number :
- edsair.doi.dedup.....16d8c856f8491e673678cfccd081d685
- Full Text :
- https://doi.org/10.1007/s12975-020-00843-8