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A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease

A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease

Authors :
Maurits A. Jansen
Joanna M. Wardlaw
Joel Ramirez
Rosalind Brown
Ian Marshall
Axel Montagne
Hedok Lee
Michael S. Stringer
Mikko T Huuskonen
Sarah Atwi
Helene Benveniste
Berislav V. Zlokovic
Bradley J. MacIntosh
Sandra E. Black
Source :
Translational Stroke Research, Stringer, M S, Lee, H, Huuskonen, M T, MacIntosh, B J, Brown, R, Montagne, A, Atwi, S, Ramirez, J, Jansen, M A, Marshall, I, Black, S E, Zlokovic, B V, Benveniste, H & Wardlaw, J M 2021, ' A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease ', Translational Stroke Research, vol. 12, no. 1, pp. 15-30 . https://doi.org/10.1007/s12975-020-00843-8
Publication Year :
2020

Abstract

Cerebral small vessel disease (SVD) is a major health burden, yet the pathophysiology remains poorly understood with no effective treatment. Since much of SVD develops silently and insidiously, non-invasive neuroimaging such as MRI is fundamental to detecting and understanding SVD in humans. Several relevant SVD rodent models are established for which MRI can monitor in vivo changes over time prior to histological examination. Here, we critically review the MRI methods pertaining to salient rodent models and evaluate synergies with human SVD MRI methods. We found few relevant publications, but argue there is considerable scope for greater use of MRI in rodent models, and opportunities for harmonisation of the rodent-human methods to increase the translational potential of models to understand SVD in humans. We summarise current MR techniques used in SVD research, provide recommendations and examples and highlight practicalities for use of MRI SVD imaging protocols in pre-selected, relevant rodent models. Electronic supplementary material The online version of this article (10.1007/s12975-020-00843-8) contains supplementary material, which is available to authorised users.

Details

ISSN :
1868601X
Volume :
12
Issue :
1
Database :
OpenAIRE
Journal :
Translational stroke research
Accession number :
edsair.doi.dedup.....16d8c856f8491e673678cfccd081d685
Full Text :
https://doi.org/10.1007/s12975-020-00843-8