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From macroprolactinoma to concomitant ACTH-PRL hypersecretion with Cushing's disease
- Source :
- Journal of endocrinological investigation. 23(2)
- Publication Year :
- 2000
-
Abstract
- Multiple pituitary hormone hypersecretions have been already described, but the combination of PRL and ACTH excess is rare. This report deals with a 42-yr-old woman affected by macroprolactinoma (PRL 12,720 microg/l, huge tumor with extrasellar extension at imaging). After one year on dopaminergic treatment causing PRL normalization and tumor shrinkage, she developed hypercortisolism (UFC 1,000 microg/24 h, ACTH 200 ng/l). Cushing's disease was diagnosed. After neurosurgery (at immunocytochemistry mixed ACTH-PRL adenoma was shown) hypercortisolism remitted, whereas pathological hyperprolactinemia with tumor remnant in cavernous sinus persisted and hypopituitarism developed. The patient reported seems atypical for the following reasons: 1) the concomitant PRL and ACTH hypersecretions; 2) the clinical presentation with hypercortisolism following hyperprolactinemia; 3) the surgical cure of hypercortisolism with persisting hyperprolactinemia.
- Subjects :
- Adult
endocrine system
Pituitary gland
medicine.medical_specialty
Adenoma
Endocrinology, Diabetes and Metabolism
Hypopituitarism
Cushing syndrome
Endocrinology
Postoperative Complications
Adrenocorticotropic Hormone
Internal medicine
Medicine
Humans
Pituitary Neoplasms
Prolactinoma
Macroprolactinoma
Cushing Syndrome
business.industry
Cushing's disease
medicine.disease
Prolactin
Radiography
medicine.anatomical_structure
Concomitant
Cavernous sinus
Female
business
hormones, hormone substitutes, and hormone antagonists
Diabetes Insipidus
Subjects
Details
- ISSN :
- 03914097
- Volume :
- 23
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of endocrinological investigation
- Accession number :
- edsair.doi.dedup.....172492f60716a0794008f54b29bd57b8