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Association of interferon-γ and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes
- Source :
- Clinical and Experimental Immunology. Wiley
- Publication Year :
- 2006
- Publisher :
- Blackwell Science Inc, 2006.
-
Abstract
- Summary We studied whether serum interferon (IFN)-γ or interleukin (IL)-10 levels and their corresponding functional polymorphic genotypes are associated with partial remission of type 1 diabetes (T1D). A multi-centre study was undertaken in patients with newly diagnosed T1D and matched controls. T1D patients were followed for 3 months and characterized for remission status. Partial clinical remission was defined as a daily insulin dose ≤ 0.38 units/kg/24 h with an HbA1c ≤ 7.5%. Thirty-three patients and 32 controls were phenotyped for serum concentrations of IFN-γ and IL-10 and genotyped for functional polymorphisms of the IFN-γ and IL-10 genes. Sixteen of 25 informative patients (63%) remitted. Serum IFN-γ concentrations were significantly decreased in remitters but increased in non-remitters compared to controls, and did not change over time in any group. IFN-γ genotypes corresponded with serum levels in controls and non-remitters, but not in remitters who displayed the lowest serum IFN-γ levels despite more often carrying high-producing IFN-γ genotypes. Neither the frequency of IL-10 genotypes nor serum IL-10 concentration differed between patients and controls. The combination of high-producing IFN-γ genotype together with low serum IFN-γ concentration at the time of diagnosis provided a strong positive predictive value for remission. Serum IFN-γ concentrations predicted by genotype and observed serum levels were discordant in remitters, suggestive of regulation overruling genetic predisposition. Although high-producing genotypes were less frequent in remitters, they were predictive of remission in combination with low serum IFN-γ levels. These data imply that remission is partially immune-mediated and involves regulation of IFN-γ transcription.
- Subjects :
- medicine.medical_specialty
Genotype
Immunology
Remission, Spontaneous
030209 endocrinology & metabolism
Spontaneous remission
03 medical and health sciences
Interferon-gamma
0302 clinical medicine
Immunopathology
Internal medicine
Diabetes mellitus
Clinical Studies
Genetic predisposition
medicine
Immunology and Allergy
Humans
Genetic Predisposition to Disease
030304 developmental biology
0303 health sciences
Type 1 diabetes
Analysis of Variance
Chi-Square Distribution
business.industry
Case-control study
Interleukin
medicine.disease
3. Good health
Interleukin-10
Endocrinology
Diabetes Mellitus, Type 1
Case-Control Studies
Sample Size
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 00099104
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Immunology. Wiley
- Accession number :
- edsair.doi.dedup.....1731e4d6f809048aae4718f368598edc