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Fundamentally different strategies for transcriptional regulation are revealed by information-theoretical analysis of binding motifs
- Publication Year :
- 2008
-
Abstract
- To regulate a particular gene, a transcription factor (TF) needs to bind a specific genome location. How is this genome address specified amid the presence of ~10^6-10^9 decoy sites? Our analysis of 319 known TF binding motifs clearly demonstrates that prokaryotes and eukaryotes use strikingly different strategies to target TFs to specific genome locations; eukaryotic TFs exhibit widespread nonfunctional binding and require clustering of sites in regulatory regions for specificity.<br />4 pages, 2 figures, expanded Supplementary Methods, Figures and Tables
- Subjects :
- Genomics (q-bio.GN)
Quantitative Biology - Subcellular Processes
Quantitative Biology - Biomolecules
Molecular Networks (q-bio.MN)
FOS: Biological sciences
Populations and Evolution (q-bio.PE)
Biomolecules (q-bio.BM)
Quantitative Biology - Genomics
Quantitative Biology - Molecular Networks
Quantitative Biology - Populations and Evolution
Subcellular Processes (q-bio.SC)
Quantitative Biology - Quantitative Methods
Quantitative Methods (q-bio.QM)
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....17396673a9ad1b35e9927f08cf2cdb8a