Investigation of dimyristoyl phosphatidyl glycerol and cholesterol based nanocochleates as a potential oral delivery carrier for methotrexate

Authors :: Bothiraja Chellampillai
Sneha Kashid
Atmaram Pawar
Ashwin Mali
Source :: Journal of Liposome Research. 32:308-316
Publication Year :: 2021
Publisher :: Informa UK Limited, 2021.
Abstract: Methotrexate (MTX), a biopharmaceutical classification system-IV anticancer drug, exhibits low therapeutic efficacy. Moreover, its clinical applications were restricted due to its multidrug resistance (MDR) in cancer and its toxic effects. The present investigation was to fabricate 1, 2-dimyristoyl

Subjects :: Excipients
Drug Carriers
Methotrexate
Cholesterol
Liposomes
Animals
Pharmaceutical Science
Calcium
Phosphatidylglycerols
Particle Size
Rats

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