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Differing time dependencies of object recognition memory impairments produced by nicotinic and muscarinic cholinergic antagonism in perirhinal cortex
- Source :
- Tinsley, C J, Fontaine-Palmer, N S, Vincent, M, Endean, E P E, Aggleton, J P, Brown, M W & Warburton, E C 2011, ' Differing time dependencies of object recognition memory impairments produced by nicotinic and muscarinic cholinergic antagonism in perirhinal cortex ', Learning and Memory, vol. 18, pp. 484-492 . https://doi.org/10.1101/lm.2274911
- Publication Year :
- 2011
- Publisher :
- Cold Spring Harbor Laboratory, 2011.
-
Abstract
- The roles of muscarinic and nicotinic cholinergic receptors in perirhinal cortex in object recognition memory were compared. Rats' discrimination of a novel object preference test (NOP) test was measured after either systemic or local infusion into the perirhinal cortex of the nicotinic receptor antagonist methyllycaconitine (MLA), which targets alpha-7 (alpha 7) amongst other nicotinic receptors or the muscarinic receptor antagonists scopolamine, AFDX-384, and pirenzepine. Methyllycaconitine administered systemically or intraperirhinally before acquisition impaired recognition memory tested after a 24-h, but not a 20-min delay. In contrast, all three muscarinic antagonists produced a similar, unusual pattern of impairment with amnesia after a 20-min delay, but remembrance after a 24-h delay. Thus, the amnesic effects of nicotinic and muscarinic antagonism were doubly dissociated across the 20-min and 24-h delays. The same pattern of shorter-term but not longer-term memory impairment was found for scopolamine whether the object preference test was carried out in a square arena or a Y-maze and whether rats of the Dark Agouti or Lister-hooded strains were used. Coinfusion of MLA and either scopolamine or AFDX-384 produced an impairment profile matching that for MLA. Hence, the antagonists did not act additively when coadministered. These findings establish an important role in recognition memory for both nicotinic and muscarinic cholinergic receptors in perirhinal cortex, and provide a challenge to simple ideas about the role of cholinergic processes in recognition memory: The effects of muscarinic and nicotinic antagonism are neither independent nor additive. The roles of muscarinic and nicotinic cholinergic receptors in perirhinal cortex in object recognition memory were compared. Rats' discrimination of a novel object preference test (NOP) test was measured after either systemic or local infusion into the perirhinal cortex of the nicotinic receptor antagonist methyllycaconitine (MLA), which targets alpha-7 (alpha 7) amongst other nicotinic receptors or the muscarinic receptor antagonists scopolamine, AFDX-384, and pirenzepine. Methyllycaconitine administered systemically or intraperirhinally before acquisition impaired recognition memory tested after a 24-h, but not a 20-min delay. In contrast, all three muscarinic antagonists produced a similar, unusual pattern of impairment with amnesia after a 20-min delay, but remembrance after a 24-h delay. Thus, the amnesic effects of nicotinic and muscarinic antagonism were doubly dissociated across the 20-min and 24-h delays. The same pattern of shorter-term but not longer-term memory impairment was found for scopolamine whether the object preference test was carried out in a square arena or a Y-maze and whether rats of the Dark Agouti or Lister-hooded strains were used. Coinfusion of MLA and either scopolamine or AFDX-384 produced an impairment profile matching that for MLA. Hence, the antagonists did not act additively when coadministered. These findings establish an important role in recognition memory for both nicotinic and muscarinic cholinergic receptors in perirhinal cortex, and provide a challenge to simple ideas about the role of cholinergic processes in recognition memory: The effects of muscarinic and nicotinic antagonism are neither independent nor additive.
- Subjects :
- Male
Cognitive Neuroscience
Muscarinic Antagonists
Nicotinic Antagonists
Receptors, Nicotinic
Time
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Perirhinal cortex
Muscarinic acetylcholine receptor
medicine
Muscarinic acetylcholine receptor M4
Animals
Recognition memory
Cerebral Cortex
Methyllycaconitine
Research
Recognition, Psychology
Receptors, Muscarinic
Pirenzepine
Rats
Memory, Short-Term
Neuropsychology and Physiological Psychology
medicine.anatomical_structure
Nicotinic agonist
chemistry
Cholinergic
Psychology
Neuroscience
medicine.drug
Subjects
Details
- ISSN :
- 15495485
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Learning & Memory
- Accession number :
- edsair.doi.dedup.....174b16467caa6aa884c483ddbf7a34e6