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A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk
- Source :
- Cancer Research, Cancer Research, American Association for Cancer Research, 2019, 79 (1), pp.274-285. ⟨10.1158/0008-5472.CAN-18-2318⟩, Cancer research, vol 79, iss 1, Travis, R C, Martin, R & Donovan, J 2018, ' A collaborative analysis of individual participant data from 19 prospective studies assesses circulating vitamin D and prostate cancer risk ', Cancer Research . https://doi.org/10.1158/0008-5472.CAN-18-2318, Cancer Research, 79(1), 274. American Association for Cancer Research Inc.
- Publication Year :
- 2019
-
Abstract
- Previous prospective studies assessing the relationship between circulating concentrations of vitamin D and prostate cancer risk have shown inconclusive results, particularly for risk of aggressive disease. In this study, we examine the association between prediagnostic concentrations of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] and the risk of prostate cancer overall and by tumor characteristics. Principal investigators of 19 prospective studies provided individual participant data on circulating 25(OH)D and 1,25(OH)2D for up to 13,462 men with incident prostate cancer and 20,261 control participants. ORs for prostate cancer by study-specific fifths of season-standardized vitamin D concentration were estimated using multivariable-adjusted conditional logistic regression. 25(OH)D concentration was positively associated with risk for total prostate cancer (multivariable-adjusted OR comparing highest vs. lowest study-specific fifth was 1.22; 95% confidence interval, 1.13–1.31; P trend < 0.001). However, this association varied by disease aggressiveness (Pheterogeneity = 0.014); higher circulating 25(OH)D was associated with a higher risk of nonaggressive disease (OR per 80 percentile increase = 1.24, 1.13–1.36) but not with aggressive disease (defined as stage 4, metastases, or prostate cancer death, 0.95, 0.78–1.15). 1,25(OH)2D concentration was not associated with risk for prostate cancer overall or by tumor characteristics. The absence of an association of vitamin D with aggressive disease does not support the hypothesis that vitamin D deficiency increases prostate cancer risk. Rather, the association of high circulating 25(OH)D concentration with a higher risk of nonaggressive prostate cancer may be influenced by detection bias. Significance: This international collaboration comprises the largest prospective study on blood vitamin D and prostate cancer risk and shows no association with aggressive disease but some evidence of a higher risk of nonaggressive disease.
- Subjects :
- Male
0301 basic medicine
Oncology
1,25-dihydroxyvitamin D
Aging
Cancer Research
MESH: Risk Assessment/methods
MESH: Prostatic Neoplasms/etiology
Disease
Prostate cancer
0302 clinical medicine
Risk Factors
MESH: Risk Factors
Odds Ratio
Prospective Studies
Vitamin D
Prospective cohort study
ComputingMilieux_MISCELLANEOUS
Cancer
MESH: Aged
MESH: Middle Aged
Prostate Cancer
Middle Aged
25-hydroxyvitamin D
MESH: Case-Control Studies
3. Good health
d metabolites
Centre for Surgical Research
030220 oncology & carcinogenesis
ICEP
pooled analysis
Risk assessment
Life Sciences & Biomedicine
Urologic Diseases
medicine.medical_specialty
Clinical Trials and Supportive Activities
Oncology and Carcinogenesis
[SDV.CAN]Life Sciences [q-bio]/Cancer
Risk Assessment
Article
vitamin D deficiency
03 medical and health sciences
MESH: Cross-Sectional Studies
serum 25-hydroxyvitamin d
Clinical Research
subsequent development
Internal medicine
1,25-DIHYDROXYVITAMIN-D
medicine
Vitamin D and neurology
Journal Article
Humans
Oncology & Carcinogenesis
MESH: Vitamin D/blood
Aged
Nutrition
Science & Technology
MESH: Humans
business.industry
Prevention
Case-control study
Prostatic Neoplasms
Odds ratio
medicine.disease
MESH: Male
MESH: Odds Ratio
MESH: Prospective Studies
Cross-Sectional Studies
030104 developmental biology
1,25-dihydroxivatmin-d
Case-Control Studies
MESH: Vitamin D/analogs & derivatives
MESH: Prostatic Neoplasms/blood
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
polymorphisms
1112 Oncology And Carcinogenesis
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Subjects
Details
- Language :
- English
- ISSN :
- 00085472 and 15387445
- Database :
- OpenAIRE
- Journal :
- Cancer Research, Cancer Research, American Association for Cancer Research, 2019, 79 (1), pp.274-285. ⟨10.1158/0008-5472.CAN-18-2318⟩, Cancer research, vol 79, iss 1, Travis, R C, Martin, R & Donovan, J 2018, ' A collaborative analysis of individual participant data from 19 prospective studies assesses circulating vitamin D and prostate cancer risk ', Cancer Research . https://doi.org/10.1158/0008-5472.CAN-18-2318, Cancer Research, 79(1), 274. American Association for Cancer Research Inc.
- Accession number :
- edsair.doi.dedup.....17500b64f3387521b82e57061fa91529