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Expression of MUPP1 protein in mouse brain
- Source :
- Brain Research. 970:178-187
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- Localizing cell surface receptors to specific subcellular sites can be crucial for proper functioning. PDZ proteins apparently play central roles in such protein localizations. 5-HT 2C receptors have previously been shown to interact with MUPP1, a multi PDZ domain protein, in heterologous systems and in rat choroid plexus. We now report the generation and characterization of two independent MUPP1 antisera, which recognise distinct areas of the mouse brain in agreement with previous in-situ hybridization studies. Our results indicate that MUPP1 immunoreactivity co-localizes with 5-HT 2A or 5-HT 2C receptor expression in all regions of the mouse brain, including the choroid plexus where 5-HT 2C receptors are highly enriched.
- Subjects :
- Male
Receptor expression
PDZ domain
Biology
Mice
Cell surface receptor
Gene expression
Animals
Humans
Receptor
Molecular Biology
5-HT receptor
Brain Chemistry
General Neuroscience
5-HT2 receptor
Intracellular Signaling Peptides and Proteins
Brain
Membrane Proteins
Recombinant Proteins
Rats
Cell biology
Mice, Inbred C57BL
Gene Expression Regulation
Female
Choroid plexus
Neurology (clinical)
Carrier Proteins
Neuroscience
Developmental Biology
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 970
- Database :
- OpenAIRE
- Journal :
- Brain Research
- Accession number :
- edsair.doi.dedup.....176324f9fa33cae9bdcbceedeb1f13f0