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Role of a natural integrator based on lipoic acid, palmitoiletanolamide and myrrh in the treatment of chronic pelvic pain and endometriosis
- Publication Year :
- 2019
-
Abstract
- Background Dysmenorrhea and chronic pelvic pain occur in a significantly higher percentage in women with endometriosis; this benign condition has an incidence ranging from 5% to 10% in the general population, while 35% to 50% of infertile women are affected. Treatment of the symptoms demands integrated approaches with the use of anti-inflammatory substances or drugs and lifestyle changes, including attention to diet. The use of traditional anti-inflammatory drugs over the long term is not very successful because of the fear of side effects so they are almost always used with a short-term formula of 7-10 days when the woman's general condition becomes difficult to bear. In recent years, particular attention has been paid to natural substances with recognized anti-inflammatory activities that, associated with one another, are able to synergize individual actions. A nutraceutical containing substances capable of fighting chronic pelvic pain has recently been put on the market. The possible action mechanism derives from a synergy of action between alpha-lipoic acid, palmitoiletanolamide (PEA) and myrrh (Pelvinox, Laborest Italia srl, Nerviano, Milan, Italy), whose action is so effective that it is able to replace the use of anti-inflammatory drugs. The aim of the study was to evaluate the effect of these active ingredients in women with endometriosis and chronic pelvic pain. Methods This multicenter study saw the recruitment of 60 women (divided between the three centers participating in the study, Siena, Bologna and Udine) aged between 20 and 39 suffering from endometriosis (ovarian) and chronic pelvic pain. All the women took one nutraceutical (Pelvinox) at a dose of two tablets per day for 6 months. Results The results showed a significant reduction in pain symptoms as regards dyspareunia, dysmenorrhea and chronic pelvic pain, while there was no change in the mean diameter of the endometriosis cysts. Conclusions In light of the above, it is believed that substances such as alpha-lipoic acid, PEA and myrrh may play a very important role in this type of patient in the treatment of individual symptoms.
- Subjects :
- Adult
medicine.medical_specialty
Dysmenorrhea, Endometriosis, Pain
Myrrh
Population
Endometriosis
Pain
Palmitic Acids
Pelvic Pain
03 medical and health sciences
chemistry.chemical_compound
Young Adult
0302 clinical medicine
Dysmenorrhea
Internal medicine
medicine
Humans
Ovarian Diseases
Young adult
education
education.field_of_study
Analgesics
030219 obstetrics & reproductive medicine
biology
Thioctic Acid
business.industry
Terpenes
Incidence (epidemiology)
Pelvic pain
Obstetrics and Gynecology
medicine.disease
biology.organism_classification
Amides
Lipoic acid
Multicenter study
chemistry
Ethanolamines
030220 oncology & carcinogenesis
Dietary Supplements
Female
medicine.symptom
Chronic Pain
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....176338793dc7da680e684a70a3393cec