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Overexpression of serum extracellular vesicle microRNA-215-5p is associated with early tumor recurrence and poor prognosis of gastric cancêr
- Source :
- Clinics; v. 76 (2021); e2081, Clinics; Vol. 76 (2021); e2081, Clinics, Universidade de São Paulo (USP), instacron:USP, Clinics, Volume: 76, Article number: e2081, Published: 05 MAY 2021
- Publication Year :
- 2021
- Publisher :
- Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, 2021.
-
Abstract
- OBJECTIVES: Extracellular vesicle microRNAs (EV-miRNAs) have been demonstrated to be reliable candidate biomarkers for clinical applications. However, the clinical application potential of serum EV-miR-215-5p for gastric cancer (GC) remains poorly understood. The goal of our study was to determine the efficacy of serum EV-miR-215-5p in predicting the prognosis of GC. METHODS: Blood samples were collected from 118 patients with GC, 60 patients with benign gastric disease and BGD and 70 healthy controls. The relative levels of serum EV-miR-215-5p were measured using quantitative real-time polymerase chain reaction (qRT-PCR). RESULTS: Compared to patients with BGD and normal controls, GC patients exhibited remarkably higher serum EV-miR-215-5p level, especially those with early tumor recurrence (ETR). Receiver operating characteristic (ROC) curve analysis showed that serum EV-miR-215-5p was able to distinguish GC patients from BGD patients or healthy controls and GC patients with ETR from those without ETR. In addition, increased serum EV-miR-215-5p levels were notably correlated with invasive depth, TNM stage, and lymph node metastasis. Moreover, serum EV-miR-215-5p levels were greatly decreased after surgical treatment, but increased at the time of ETR. Survival analysis showed that patients with higher serum EV-miR-215-5p had shorter survival. Furthermore, serum EV-miR-215-5p was an independent risk factor for GC. CONCLUSIONS: Serum EV-miR-215-5p might be a novel biomarker for predicting ETR and prognosis of GC.
- Subjects :
- medicine.medical_specialty
Medicine (General)
Serum Extracellular Vesicle miR-215-5p
030204 cardiovascular system & hematology
Gastroenterology
Extracellular Vesicles
03 medical and health sciences
0302 clinical medicine
R5-920
Stomach Neoplasms
Internal medicine
microRNA
Diagnosis
Biomarkers, Tumor
medicine
Humans
Early Tumor Recurrence
030212 general & internal medicine
Stage (cooking)
Risk factor
Survival analysis
Receiver operating characteristic
business.industry
Cancer
General Medicine
Extracellular vesicle
medicine.disease
Prognosis
MicroRNAs
Gastric Cancer
Biomarker (medicine)
Original Article
Neoplasm Recurrence, Local
business
Subjects
Details
- Language :
- English
- ISSN :
- 19805322 and 18075932
- Database :
- OpenAIRE
- Journal :
- Clinics; v. 76 (2021); e2081, Clinics; Vol. 76 (2021); e2081, Clinics, Universidade de São Paulo (USP), instacron:USP, Clinics, Volume: 76, Article number: e2081, Published: 05 MAY 2021
- Accession number :
- edsair.doi.dedup.....1791bf7b5aff19a59216c84e2bd4d4a3