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Efficacy of different regimens of adjuvant radiochemotherapy for treatment of glioblastoma
- Source :
- Scopus-Elsevier
- Publication Year :
- 2007
-
Abstract
- Aims and background We retrospectively analyzed the impact of different adjuvant chemotherapy regimens in a group of patients treated for glioblastoma compared to patients receiving only postoperative radiotherapy. Material and methods Eighty-six consecutive patients underwent radiotherapy between January 2000 and December 2003: 52 patients received radiotherapy alone, 17 patients radiochemotherapy with low-dose temozolomide (20 mg/m2) + cyclooxygenase-2-inhibitors (200 mg), 6 patients radiochemotherapy with high-dose temozolomide (50 mg/m2). Eleven patients, with unfavorable prognostic factors, were treated with imatinib and 55/2.5 Gy. Results The groups treated with high- and low-dose temozolomide showed the longest overall survival (median, 21 months and 17 months, respectively). Median overall survival was 9 months for radiation alone and 4 months for the imatinibtreated group. The same positive trend of temozolomide on prolonged overall survival was confirmed when only patients submitted to maximally radical resection or patients with KPS >70 were considered. Differences in progression-free survival were not statistically significant. Conclusions Patients treated with adjuvant temozolomide either inside or outside of study protocols had survival times similar to other reports or randomized studies. The absence of a significant influence of temozolomide on progression-free survival could depend on the unavoidable drawbacks and biases of retrospective investigations or on the definition of relapse used. The unsatisfactory results of radiotherapy plus imatinib may have been due to a high prevalence of unfavorable prognostic factors in the respective patients. The ongoing controlled trial will further define the efficacy of adjuvant/concomitant imatinib.
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Adjuvant chemotherapy
medicine.medical_treatment
Postoperative radiotherapy
Antineoplastic Agents
Kaplan-Meier Estimate
Piperazines
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Internal medicine
Temozolomide
medicine
Humans
Chemotherapy
Aged
Retrospective Studies
Aged, 80 and over
Cyclooxygenase 2 Inhibitors
Radiotherapy
Brain Neoplasms
business.industry
Imatinib
General Medicine
Middle Aged
medicine.disease
Surgery
Dacarbazine
Radiation therapy
Pyrimidines
Chemotherapy, Adjuvant
030220 oncology & carcinogenesis
Benzamides
Imatinib Mesylate
Female
Radiotherapy, Adjuvant
business
Glioblastoma
Adjuvant
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....1797df5d2bc135a4770da78b993674bf