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Probenecid in the treatment of neurosyphilis in men who have sex with men: a commentary
- Source :
- Sexually transmitted infections. 98(6)
- Publication Year :
- 2021
-
Abstract
- Probenecid is a uricosuric drug, which inhibits the renal excretion of procaine penicillin via inhibition of the organic anion transporter (OAT-1) system in the proximal renal tubule producing higher plasma and cerebrospinal fluid (CSF) penicillin levels.1 2 Oral probenecid is recommended to be used with intramuscular procaine penicillin for the treatment of neurosyphilis. Rates of syphilis and neurosyphilis have increased significantly over the past 20 years particularly in men who have sex with men (MSM). There …
- Subjects :
- Male
Uricosuric
Organic anion transporter 1
Physiology
HIV Infections
Dermatology
urologic and male genital diseases
Men who have sex with men
Neurosyphilis
Procaine
Sexual and Gender Minorities
polycyclic compounds
medicine
Humans
Syphilis
Homosexuality, Male
biology
business.industry
Probenecid
medicine.disease
Penicillin
Infectious Diseases
biology.protein
business
medicine.drug
Subjects
Details
- ISSN :
- 14723263
- Volume :
- 98
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Sexually transmitted infections
- Accession number :
- edsair.doi.dedup.....179d5f6d0edfba704a84a75516a98f3e