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Sex, age, and ethnic dependency of lipoprotein variants as the risk factors of ischemic heart disease: a detailed study on the different age-classes and genders in Tehran Cardiometabolic Genetic Study (TCGS)
- Source :
- Biology of Sex Differences, Vol 13, Iss 1, Pp 1-10 (2022), Biology of Sex Differences
- Publication Year :
- 2022
- Publisher :
- Springer Science and Business Media LLC, 2022.
-
Abstract
- Biological processes involving environmental and genetic factors drive the interplay between age- and sex-regulating lipid profile. The relation between variations in the LPA gene with increasing the risk of coronary heart disease is dependent on population differences, sex, and age. The present study tried to do a gene candidate association analysis in people with myocardial infarction (MI) in a 22 year cohort family-based longitudinal cohort study, Tehran Cardiometabolic Genetic Study (TCGS). After adjusting p value by the FDR method, only the association of rs6415084 with the MI probability and the age-of-CHD-onset was significant in males in their middle age (p LPA and heart disease risk. Our observations may provide new insights into the biology that underlies lipid profile with age or the sexual dimorphism of Lp(a) metabolism. Finally, Lp(a) appears to be an independent risk factor; however, the role of sex and ethnicity is important.
- Subjects :
- Male
Myocardial infarction (MI)
Physiology
Myocardial Infarction
Coronary Disease
LPA locus
Iran
Age-of-onset
Gender Studies
Age
Endocrinology
Lp(a)
Risk Factors
Lipoprotein (a)
Ethnicity
Humans
QP1-981
Longitudinal Studies
TCGS
Research
Middle Aged
Single nucleotide polymorphism
Medicine
Female
Sex
Lipoprotein(a)
Subjects
Details
- ISSN :
- 20426410
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Biology of Sex Differences
- Accession number :
- edsair.doi.dedup.....179e349a5dc8968b0feafc416b8aef69