Back to Search
Start Over
Selective Reduction of α,β-Unsaturated Weinreb Amides in the Presence of α,β-Unsaturated Esters
- Source :
- Chemical and Pharmaceutical Bulletin. 68:1100-1103
- Publication Year :
- 2020
- Publisher :
- Pharmaceutical Society of Japan, 2020.
-
Abstract
- α,β-Unsaturated esters were selectively protected in situ in the presence of α,β-unsaturated Weinreb amides using PEt3 and trimethylsilyl trifluoromethanesulfonate (TMSOTf) in toluene under reflux. Diisobutylaluminium hydride (DIBAL-H) reduction of the mixture followed by tetra-n-butylammonium fluoride (TBAF) treatment produced α,β-unsaturated aldehydes in good yields along with the recovered α,β-unsaturated esters.
Details
- ISSN :
- 13475223 and 00092363
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Chemical and Pharmaceutical Bulletin
- Accession number :
- edsair.doi.dedup.....17a71c2a496ffa3aca147a4306fb7d59