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Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans
- Source :
- Science. 347:83-86
- Publication Year :
- 2015
- Publisher :
- American Association for the Advancement of Science (AAAS), 2015.
-
Abstract
- Lysosomes signal the nucleus to control aging Folick et al. propose a mechanism by which a lysosomal enzyme influences nuclear events that control longevity in the worm (see the Perspective by Shuo and Brunet). Increased expression of the lysosomal acid lipase LIPL-4 increased longevity, and this effect depended on the presence of the lysosomal lipid-binding protein LBP-8. LBP-8 acts as a chaperone that helps carry lipds to the nucleus. The authors identified the fatty acid oleoylethanolamide (OEA) as a potential signaling molecule whose transport to the nucleus could activate nuclear hormone receptors and transcription factors NHR-49 and NHR-80. The transcriptional targets of NHR-49 and NHR-80 in turn regulate longevity. Science , this issue p. 83
- Subjects :
- Cell signaling
animal structures
media_common.quotation_subject
Longevity
Active Transport, Cell Nucleus
Receptors, Cytoplasmic and Nuclear
Article
Organelle
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
media_common
Cell Nucleus
Multidisciplinary
biology
Lipase
Lipid Metabolism
biology.organism_classification
Cell biology
Nuclear receptor
Biochemistry
Chaperone (protein)
biology.protein
Signal transduction
Lysosomes
Intracellular
Signal Transduction
Molecular Chaperones
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 347
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....17acac98bacd798e87c6acb9c4c83dfd