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Association between neutrophil-lymphocyte & platelet lymphocyte ratios with prognosis & mortality in rapidly progressive glomerulonephritis
- Source :
- Indian Journal of Medical Research, Vol 150, Iss 4, Pp 399-406 (2019), The Indian Journal of Medical Research
- Publication Year :
- 2019
- Publisher :
- Medknow, 2019.
-
Abstract
- Background & objectives: Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome manifested by features of nephritic syndrome and progressive loss of renal function over a short time. The objective of this study was to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and prognostic factors and pathological findings of renal biopsy in RPGN. Methods: Consecutive newly diagnosed RPGN patients who had follow up for at least six months were retrospectively analyzed. The estimated glomerular filtration rate (EGFR) was calculated. Albumin, C-reactive protein (CRP) levels and CRP/albumin ratio were also calculated. Results: Fifty four patients were included in the study. The mean age was 48.92±20.12 years. Clinicopathological diagnosis was pauci-immune glomerulonephritis (GN) in 40 while two had postinfectious GN, six systemic lupus erythematosus, three IgA nephropathy, two Henoch-Schönlein purpura and one membranoproliferative GN. The mean NLR was 7.02±6.34 and mean PLR was 273.90±39.15. Positive correlations between NLR and CRP levels (P=0.009, r=0.511) and CRP/albumin ratios (P=0.005, r=0.542) were observed. PLR and CRP/albumin ratios (P=0.041, r=0.412) were correlated positively. The per cent of fibrocellular crescents was negatively correlated with NLR (P=0.019, r=-0.291), and positively correlated with the lymphocyte count (P=0.05, r=0.256). In secondary crescentic subgroup, the per cent of fibrinoid necrosis had a positive correlation with PLR (P=0.013, r=0.642). Both NLR (P=0.036) and PLR (P=0.051) detected at the first month of the treatment period, were observed to be significantly correlated with mortality. Interpretation & conclusions: This study showed that NLR could predict mortality in patients with RPGN; correlated with systemic inflammation; showed a negative correlation with the per cent of fibrocellular crescents and could be regarded as a measure of glomerular inflammatory state. Moreover, PLR may be considered to be an indicator of disease severity in acute phase of crescentic GN. © 2019 Indian Journal of Medical Research.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Neutrophils
030106 microbiology
lcsh:Medicine
Renal function
Kidney
Gastroenterology
General Biochemistry, Genetics and Molecular Biology
Nephropathy
Leukocyte Count
03 medical and health sciences
Nephritic syndrome
Glomerulonephritis
0302 clinical medicine
neutrophil-to-lymphocyte ratio
renal pathology
Crescentic glomerulonephritis
Internal medicine
RPGN
Humans
Medicine
Rapidly progressive glomerulonephritis
Lymphocytes
030212 general & internal medicine
crescentic glomerulonephritis - neutrophil-to-lymphocyte ratio - platelet-to-lymphocyte ratio - renal pathology - rpgn
Neutrophil to lymphocyte ratio
Fibrinoid necrosis
Aged
medicine.diagnostic_test
Platelet Count
business.industry
lcsh:R
General Medicine
Middle Aged
Prognosis
medicine.disease
platelet-to-lymphocyte ratio
C-Reactive Protein
Original Article
Female
Renal biopsy
business
Subjects
Details
- ISSN :
- 09715916
- Volume :
- 150
- Database :
- OpenAIRE
- Journal :
- Indian Journal of Medical Research
- Accession number :
- edsair.doi.dedup.....17af77d60c1f3bd698a53c47ee7ca190