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Fluorescent glycoconjugates and their applications

Authors :
Baptiste Thomas
Xi-Le Hu
Guo-Rong Chen
Marion Donnier-Maréchal
Kai-Cheng Yan
Sébastien Vidal
Xiao-Peng He
Chimie Organique 2-Glycochimie (CO2GLYCO)
Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS)
Université Claude Bernard Lyon 1 (UCBL)
Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon)
Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL)
Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)
Source :
Chemical Society Reviews, Chemical Society Reviews, Royal Society of Chemistry, 2020, 49 (2), pp.593-641. ⟨10.1039/C8CS00118A⟩
Publication Year :
2020
Publisher :
HAL CCSD, 2020.

Abstract

International audience; Glycoconjugates and their applications as lectin ligands in biology has been thoroughly investigated in the past decades. Meanwhile, the intrinsic properties of such multivalent molecules were limited essentially to their ability to bind to their receptors with high selectivity and/or avidity. The present review will focus on multivalent glycoconjugates displaying an additional capability such as fluorescence properties for applications toward imaging of cancer cells, detection of proteins or pathogens but also for drug delivery systems toward targeted cancer therapy. This review is a collection of research articles discussed in the context of the structural features of the fluorescent glycoconjugates organized according to their fluorescent core scaffold and with their representative applications.

Details

Language :
English
ISSN :
03060012 and 14604744
Database :
OpenAIRE
Journal :
Chemical Society Reviews, Chemical Society Reviews, Royal Society of Chemistry, 2020, 49 (2), pp.593-641. ⟨10.1039/C8CS00118A⟩
Accession number :
edsair.doi.dedup.....17b2c38117d568089044fffed77205cd
Full Text :
https://doi.org/10.1039/C8CS00118A⟩