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Identification of 14-3-3 protein isoforms in human astrocytoma by immunohistochemistry
- Source :
- Neuroscience Letters. 432:94-99
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- The 14-3-3 proteins are highly conserved, ubiquitous molecules involved in a variety of biologic events, such as cell cycle control, and apoptosis. In our previous study, it has been proved that they are expressed in primary human nervous system tumors. However, the isoform-specific expression of 14-3-3 protein is still need to be identified. This study is the first detection of 14-3-3 isoforms' specific expression in human astrocytoma. In the normal brain tissues, all the seven 14-3-3 isoforms' immunoreactivity was localized mainly in the neurons, while only weak expression of epsilon, zeta and theta was found in some glial cells. However, beta, epsilon, zeta, eta and theta isoforms' immunoreactivity was seen in the majority of astrocytoma samples and its immunoreactivity score was increased markedly with an increase in the pathologic grade of human astrocytomas. These results indicate that the five isoforms may play an important role in tumorigenesis of human astrocytoma.
- Subjects :
- Adult
Male
Gene isoform
Nervous system
Programmed cell death
Pathology
medicine.medical_specialty
Adolescent
Apoptosis
Astrocytoma
Biology
medicine.disease_cause
Diagnosis, Differential
Predictive Value of Tests
Biomarkers, Tumor
medicine
Humans
Protein Isoforms
Child
14-3-3 protein
Aged
Neurons
Brain Neoplasms
General Neuroscience
Middle Aged
medicine.disease
Immunohistochemistry
Molecular biology
Up-Regulation
Cell Transformation, Neoplastic
medicine.anatomical_structure
14-3-3 Proteins
Astrocytes
Female
Carcinogenesis
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 432
- Database :
- OpenAIRE
- Journal :
- Neuroscience Letters
- Accession number :
- edsair.doi.dedup.....17b67dacab9571e598ff402ea43fd646