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The associations of serum S100A9 with the severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study
- Source :
- BMC Infectious Diseases, BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-9 (2021)
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Background Previous studies found that S100A9 may involve in the pathophysiology of community-acquired pneumonia (CAP). However, the role of S100A9 was unclear in the CAP. The goal was to explore the correlations of serum S100A9 with the severity and prognosis of CAP patients based on a prospective cohort study. Methods A total of 220 CAP patients and 110 control subjects were recruited. Demographic and clinical data were collected. Serum S100A9 and inflammatory cytokines were measured. Results Serum S100A9 was elevated in CAP patients on admission. Serum S100A9 was gradually elevated parallelly with CAP severity scores. Additionally, inflammatory cytokines were increased and blood routine parameters were changed in CAP patients compared with control subjects. Correlation analysis found that serum S100A9 was positively associated with CAP severity scores, blood routine parameters (WBC, NLR and MON) and inflammatory cytokines. Further, logistic regression analysis demonstrated that there were positive associations between serum S100A9 and CAP severity scores. Besides, the prognosis of CAP was tracked. Serum higher S100A9 on the early stage elevated the death of risk and hospital stay among CAP patients. Conclusion Serum S100A9 is positively correlated with the severity of CAP. On admission, serum higher S100A9 elevates the risk of death and hospital stay in CAP patients, suggesting that S100A9 may exert a certain role in the pathophysiology of CAP and regard as a serum diagnostic and managing biomarker for CAP.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Community-acquired pneumonia
Logistic regression
lcsh:Infectious and parasitic diseases
Proinflammatory cytokine
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Calgranulin B
Humans
lcsh:RC109-216
Prospective Studies
Prospective cohort study
S100A9
CAP severity score
Aged
business.industry
Patient Acuity
Biomarker
Pneumonia
Middle Aged
Inflammatory cytokines
Prognosis
medicine.disease
Pathophysiology
Community-Acquired Infections
030104 developmental biology
Infectious Diseases
030220 oncology & carcinogenesis
Biomarker (medicine)
Female
business
Biomarkers
Research Article
Cohort study
Subjects
Details
- ISSN :
- 14712334
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- BMC Infectious Diseases
- Accession number :
- edsair.doi.dedup.....17b9f969e70237e75bdea0e037144cde