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Estrogen Receptor GPR30 Reduces Oxidative Stress and Proteinuria in the Salt-Sensitive Female mRen2.Lewis Rat
- Source :
- Hypertension. 58:665-671
- Publication Year :
- 2011
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2011.
-
Abstract
- The current study assessed whether activation of the novel estrogen receptor GPR30 ameliorates salt-dependent renal damage in intact mRen2.Lewis (mRen2) females. Hemizygous mRen2 rats were maintained on either a normal salt (0.5% Na) or high-salt (HS; 4.0% Na) diet for 10 weeks (5 to 15 weeks of age), and HS animals were treated with the GPR30 agonist G-1 or vehicle for 2 weeks. Systolic blood pressure markedly increased with HS diet (149±3 to 219±5 mm Hg; P P =0.42). G-1 and estradiol induced relaxation of preconstricted mesenteric vessels from normal salt mRen2 rats, but both responses were attenuated in the HS group. Despite the lack of an effect on blood pressure, G-1 decreased renal hypertrophy, proteinuria, urinary 8-isoprostane excretion, and tubular 4-hydroxynonenal staining. HS diet significantly increased GPR30 mRNA (1.01±0.04 versus 1.59±0.13; P P
- Subjects :
- medicine.medical_specialty
Renal cortex
Estrogen receptor
Blood Pressure
Vasodilation
Cyclopentanes
Article
Receptors, G-Protein-Coupled
Kidney Tubules, Proximal
Excretion
Internal medicine
Renin
Renin–angiotensin system
Internal Medicine
medicine
Animals
Mesenteric arteries
Estradiol
Chemistry
Reabsorption
Sodium, Dietary
Salt Tolerance
Mesenteric Arteries
Rats
Low Density Lipoprotein Receptor-Related Protein-2
Oxidative Stress
Proteinuria
medicine.anatomical_structure
Blood pressure
Endocrinology
Rats, Inbred Lew
Models, Animal
Quinolines
Female
Subjects
Details
- ISSN :
- 15244563 and 0194911X
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Hypertension
- Accession number :
- edsair.doi.dedup.....17ba68c5e65538794d2a0721373de588