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Nonabsorbable Dietary Fat Enhances Disposal of 2,2‘,4,4‘-Tetrabromodiphenyl Ether in Rats through Interruption of Enterohepatic Circulation
- Source :
- Journal of Agricultural and Food Chemistry, 54(17), 6440-6444. AMER CHEMICAL SOC
- Publication Year :
- 2006
- Publisher :
- American Chemical Society (ACS), 2006.
-
Abstract
- Polybrominated diphenyl ethers are lipophilic persistent organic pollutants (POPs), which accumulate in the environment, leading to human exposure. The compounds exert a negative impact on human health. Strategies to prevent or diminish their accumulation in humans are required. We investigated in rats whether the disposal rate of C-14-labeled tetrabromodiphenyl ether (BDE-47) could be enhanced by increasing fecal fat excretion through dietary treatment with nonabsorbable fat (sucrose polyester, SPE). As compared to control rats, SPE treatment increased fecal excretion rates of fat (+188%, p
- Subjects :
- Male
medicine.medical_specialty
BDE-47
Polybrominated Biphenyls
Adipose tissue
CHILDREN
disposal
BROMINATED FLAME RETARDANTS
Intestinal absorption
Excretion
sucrose polyester
Feces
Polybrominated diphenyl ethers
POLYCHLORINATED-BIPHENYLS
Internal medicine
Enterohepatic Circulation
Halogenated Diphenyl Ethers
medicine
CONTAMINANTS
Animals
EXPOSURE
Carbon Radioisotopes
Rats, Wistar
Enterohepatic circulation
EXCRETION
Chemistry
POLYBROMINATED DIPHENYL ETHERS
Phenyl Ethers
General Chemistry
Metabolism
Carbohydrate
Dietary Fats
Diet
Hydrocarbons, Brominated
Rats
ADIPOSE-TISSUE
Endocrinology
Intestinal Absorption
GROWTH
DIOXINS
General Agricultural and Biological Sciences
metabolism
Subjects
Details
- ISSN :
- 15205118 and 00218561
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Journal of Agricultural and Food Chemistry
- Accession number :
- edsair.doi.dedup.....17bf2f4d9131a9218b1739902a6f48fa