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Celsior Preserved Cardiac Mechanoenergetics Better Than Popular Solutions in Canine Hearts
- Source :
- The Annals of Thoracic Surgery. 81:658-664
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Background Better protective effects of Celsior on cardiac function than the other conventional solutions have been reported in acute experiments and in clinical trials for at-risk patients. However, no study has yet precisely elucidated how these preservation solutions affect cardiac mechanoenergetics. Therefore, we evaluated the effects of St. Thomas' Hospital solution No. 2, University of Wisconsin solution, and Celsior on left ventricular contractility (E max : end-systolic pressure–volume ratio) and oxygen consumption. Methods We used 32 canine excised cross-circulated hearts. Twenty-three hearts served as donor hearts after hypothermic ischemia with one of the three solutions, and the remaining 9 served as controls. After arrest with each solution, the hearts were preserved for 4 hours at 4°C. Then, we measured left ventricular pressure, volume, and oxygen consumption to obtain E max and the relation between ventricular pressure–volume area (a measure of total mechanical energy) and oxygen consumption. We also evaluated the oxygen cost of E max by changing E max with calcium administration. Results Celsior did not significantly affect E max (6.3 ± 2.4 in control versus 5.3 ± 1.3 mm Hg · mL −1 · 100 g with Celsior) nor the oxygen cost of E max (1.2 ± 0.6 versus 1.6 ± 0.5 mL O 2 · mL · mm Hg −1 · beat −1 · 100 g −2 , respectively). In contrast, St. Thomas' Hospital and University of Wisconsin solutions significantly decreased E max (4.5 ± 1.1 and 3.5 ± 0.9 mm Hg · mL −1 · 100 g, respectively) and increased the oxygen cost of E max (2.5 ± 0.8 and 2.4 ± 0.9 mL O 2 · mL · mm Hg −1 · beat −1 · 100 g −2 , respectively) compared with control and Celsior-preserved hearts. The slope and intercept of the oxygen consumption versus pressure–volume area relation showed no significant difference among the four groups. Conclusions Celsior showed better protective effects on cardiac mechanoenergetics than St. Thomas' Hospital and University of Wisconsin solutions in the acute phase of heart transplantation.
- Subjects :
- Pulmonary and Respiratory Medicine
Cardiac function curve
medicine.medical_treatment
Organ Preservation Solutions
chemistry.chemical_element
Disaccharides
Oxygen
Electrolytes
Dogs
Oxygen Consumption
Glutamates
Preservation solutions
Animals
Medicine
Histidine
Mannitol
Viaspan
Heart transplantation
biology
business.industry
Fissipedia
Significant difference
Heart
biology.organism_classification
Glutathione
Myocardial Contraction
Biomechanical Phenomena
chemistry
Anesthesia
Ventricular pressure
Heart Transplantation
Surgery
Energy Metabolism
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 00034975
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- The Annals of Thoracic Surgery
- Accession number :
- edsair.doi.dedup.....17c828afcc8154c0670f43389a9d4a79