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Evaluation of Onchocerciasis Transmission in Tanzania: Preliminary Rapid Field Results in the Tukuyu Focus, 2015
- Source :
- The American journal of tropical medicine and hygiene. 97(3)
- Publication Year :
- 2017
-
Abstract
- To compare diagnostic tests for onchocerciasis in a setting that has suppressed transmission, a randomized, age-stratified study was implemented in an area in Tanzania that had received 15 rounds of annual mass drug administration (MDA) with ivermectin. Study participants (N = 948) from 11 villages underwent a questionnaire, skin examination, skin snips, and blood draw. The burden of symptomatic disease was low. Ov-16 antibody rapid diagnostic test (RDT) results were positive in 38 (5.5%) participants, with 1 (0.5%), 1 (0.4%), and 2 (0.8%) in children aged 0–5, 6–10, and 11–15 years, respectively. Despite significant impact of MDA on transmission, the area would have failed to meet World Health Organization serologic criteria for stopping MDA if a full evaluation had been conducted. The specificity of the RDT, which is 97–98%, may result in the identification of a number of false positives that would exceed the current stop MDA threshold.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Adolescent
030231 tropical medicine
Onchocerciasis
Tanzania
law.invention
Serology
03 medical and health sciences
Young Adult
0302 clinical medicine
Ivermectin
law
Virology
Internal medicine
parasitic diseases
False positive paradox
medicine
Humans
Serologic Tests
030212 general & internal medicine
Mass drug administration
Child
Anthelmintics
Rapid diagnostic test
biology
business.industry
Infant
Articles
medicine.disease
biology.organism_classification
Surgery
Infectious Diseases
Transmission (mechanics)
Child, Preschool
Parasitology
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 14761645
- Volume :
- 97
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The American journal of tropical medicine and hygiene
- Accession number :
- edsair.doi.dedup.....17d9d69917a4ec503871f5e195693c56