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Newly Explored Faecalibacterium Diversity Is Connected to Age, Lifestyle, Geography, and Disease
- Source :
- Current Biology
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Faecalibacterium is prevalent in the human gut and a promising microbe for the development of next-generation probiotics (NGPs) or biotherapeutics. Analyzing reference Faecalibacterium genomes and almost 3,000 Faecalibacterium-like metagenome-assembled genomes (MAGs) reconstructed from 7,907 human and 203 non-human primate gut metagenomes, we identified the presence of 22 different Faecalibacterium-like species-level genome bins (SGBs), some further divided in different strains according to the subject geographical origin. Twelve SGBs are globally spread in the human gut and show different genomic potential in the utilization of complex polysaccharides, suggesting that higher SGB diversity may be related with increased utilization of plant-based foods. Moreover, up to 11 different species may co-occur in the same subject, with lower diversity in Western populations, as well as intestinal inflammatory states and obesity. The newly explored Faecalibacterium diversity will be able to support the choice of strains suitable as NGPs, guided by the consideration of the differences existing in their functional potential.
- Subjects :
- Adult
0301 basic medicine
Adolescent
media_common.quotation_subject
Datasets as Topic
Faecalibacterium prausnitzii
Disease
Biology
Genome
General Biochemistry, Genetics and Molecular Biology
Feces
Young Adult
03 medical and health sciences
0302 clinical medicine
Human gut
Animals
Humans
Child
Life Style
Faecalibacterium
Phylogeny
Aged
media_common
Geography
Probiotics
Age Factors
Infant
Middle Aged
biology.organism_classification
Gut microbiome
Gastrointestinal Microbiome
Faecalibacterium prausnitzii, gut microbiome, strain diversity, pangenome, novel probiotics, biotherapeutics
030104 developmental biology
Evolutionary biology
Child, Preschool
Dysbiosis
Macaca
Metagenome
Metagenomics
General Agricultural and Biological Sciences
030217 neurology & neurosurgery
Diversity (politics)
Subjects
Details
- ISSN :
- 09609822
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Current Biology
- Accession number :
- edsair.doi.dedup.....17db7775ec82013f1472e3213595e493