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Impact of adrenomedullin levels on clinical risk stratification and outcome in subarachnoid haemorrhage

Authors :
Jaume Roquer
Francisco Alvarez-Lerma
Angel Ois
Maria Pilar Gracia Arnillas
Xavi Duran
Elisa Cuadrado
Demian Manzano
Carolina Soriano
Ans Zapatero
Andrea Castellví
Yolanda Diaz
Jose Ramón Masclans
Source :
European journal of clinical investigationREFERENCES. 50(11)
Publication Year :
2019

Abstract

PURPOSE To use classification tree analysis to identify risk factors for nonsurvival in a neurological patients with subarachnoid haemorrhage (SAH) and to propose a clinical model for predicting of mortality. METHODS Prospective study of SAH admitted to a Critical Care Department and Stroke Unit over a 2-year period. Middle region of pro-ADM plasma levels (MR-proADM) was measured in EDTA plasma within the first 24 hours of hospital admission using the automatic immunofluorescence test. A regression tree was made to identify prognostic models for the development of mortality at 90 days. RESULTS Ninety patients were included. The mean MR-proADM plasma value in the samples analysed was 0.78 ± 0.41 nmol/L. MR-proADM plasma levels were significantly associated with mortality at 90 days (1.05 ± 0.51 nmol/L vs 0.64 ± 0.25 nmol/L; P

Details

ISSN :
13652362
Volume :
50
Issue :
11
Database :
OpenAIRE
Journal :
European journal of clinical investigationREFERENCES
Accession number :
edsair.doi.dedup.....17e47ad10f3df46390cc78a6c221370d