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Common genetic variants on 8q24 contribute to susceptibility to bladder cancer in a Chinese population
- Source :
- Carcinogenesis. 30(6)
- Publication Year :
- 2009
-
Abstract
- A recent genome-wide association study identified two common variants that confer susceptibility to bladder cancer. We hypothesized that these variants are associated with risk of bladder cancer in Chinese populations. We genotyped rs9642880 G>T on 8q24 and rs710521 A>G on 3q28 in a two-stage case-control study of bladder cancer to evaluate the association and further examined the expression of MYC. We found that the rs9642880 G>T, but not the rs710521 A>G polymorphism, was associated with an increased risk of bladder cancer. Compared with the rs9642880 GG genotype, the GT/TT genotypes were associated with an odds ratio of 1.65 (95% confidence interval = 1.25-2.17), and this risk was more pronounced in young men and for low-risk tumors. Additional experiments revealed that the rs9642880 GT/TT genotypes were associated with enhanced levels of both MYC mRNA and protein in bladder tissues. Our findings suggested that the rs9642880 G>T polymorphism on 8q24 was independently associated with the risk of bladder cancer in Chinese populations.
- Subjects :
- Oncology
Male
Risk
Cancer Research
medicine.medical_specialty
Single-nucleotide polymorphism
Genome-wide association study
Biology
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-myc
Asian People
Polymorphism (computer science)
Internal medicine
Genotype
medicine
Humans
Genetic Predisposition to Disease
RNA, Messenger
Aged
Genetics
Bladder cancer
Case-control study
Cancer
General Medicine
Odds ratio
Middle Aged
medicine.disease
Urinary Bladder Neoplasms
Case-Control Studies
Female
Chromosomes, Human, Pair 8
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 14602180
- Volume :
- 30
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Carcinogenesis
- Accession number :
- edsair.doi.dedup.....17ee9f04bf33d3760138ee3311a7796d