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Surveillance Imaging after Autologous Hematopoietic Cell Transplantation Predicts Survival in Patients with Diffuse Large B Cell Lymphoma
- Source :
- Biology of Blood and Marrow Transplantation. 26:272-277
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- The utility of surveillance imaging after autologous hematopoietic cell transplantation (AHCT) in relapsed/refractory diffuse large B cell lymphoma (DLBCL) remains unclear. The purpose of this study was to determine whether surveillance imaging predicts survival after AHCT. At the University of Minnesota, serial imaging for early relapse detection has been used prospectively for all consecutive AHCT recipients treated since 2010. The present analysis included 91 AHCT recipients with DLBCL who underwent 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) scan at day +100 post-AHCT. 18F-FDG-PET parameters included the Deauville (D) 5-point scale, peak standardized uptake values (SUVmax), total legion glycolysis (TLG), and total metabolic tumor volume (TMTV). Survival of patients with clinically symptomatic versus asymptomatic radiographically detected relapsed DLBCL after AHCT was compared. Sixty patients experienced relapse; 35% was detected on day +100 surveillance PET scan. 5-year overall survival (OS) by 18F-FDG-PET scan at day +100 post-AHCT was significantly lower in D4 and D5 patients (37%; 95% confidence interval [CI], 14% to 100% versus 25%; 95% CI, 43% to 89%) compared with patients with D1 and D2 (62%; 95% CI, 43% to 89% versus 62%; 95% CI, 46% to 84%). TLG and TMTV were not prognostic. SUVmax at day +100 varied from 1.5 (D1) to 17.9 (D5). In multivariate analysis, only SUVmax was predictive of relapse and OS; mortality increased 1.8-fold with each SUVmax doubling (hazard ratio [HR], 1.8; 95% CI, 1.3 to 2.3; P
- Subjects :
- medicine.medical_specialty
Transplantation, Autologous
Asymptomatic
Gastroenterology
Fluorodeoxyglucose F18
Internal medicine
Humans
Medicine
Refractory Diffuse Large B-Cell Lymphoma
Retrospective Studies
Transplantation
medicine.diagnostic_test
business.industry
Hazard ratio
Hematopoietic Stem Cell Transplantation
Hematology
medicine.disease
Confidence interval
Positron emission tomography
Positron-Emission Tomography
Lymphoma, Large B-Cell, Diffuse
Neoplasm Recurrence, Local
Surveillance imaging
medicine.symptom
business
Diffuse large B-cell lymphoma
Subjects
Details
- ISSN :
- 10838791
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Biology of Blood and Marrow Transplantation
- Accession number :
- edsair.doi.dedup.....180cebaf1b490caf48252f8edb2c6dd4