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Management of locally advanced breast cancer: evolution and current practice
- Source :
- Journal of Cancer Research and Therapeutics, Vol 1, Iss 1, Pp 21-30 (2005)
- Publication Year :
- 2007
-
Abstract
- Locally advanced breast cancer (LABC) accounts for a sizeable number (30-60%) of breast cancer cases and is a common clinical scenario in developing countries. The treatment of LABC has evolved from single modality treatment, consisting of radical mutilating surgery or higher doses of radiotherapy in inoperable disease to multimodality management, which along with the above two included systemic therapy. Neoadjuvant chemotherapy (NACT) has made a tremendous impact on the management of LABC. NACT was initiated to institute systemic therapy upfront at the earliest in this group of patients with a high risk of micrometastasis burden. While NACT did not yield a survival advantage, it has however made breast conservation possible in selected group of cases. Large number of studies and many randomised trials have been done in women with LABC in order to improve the therapeutic decisions and also the local control and survival. With this background we have reviewed various treatment options in patients with LABC which should possibly help in guiding the clinicians for optimal management of LABC.
- Subjects :
- Oncology
medicine.medical_specialty
medicine.medical_treatment
Locally advanced
MEDLINE
Antineoplastic Agents
Breast Neoplasms
Disease
Systemic therapy
lcsh:RC254-282
Breast cancer
Internal medicine
medicine
Combined Modality Therapy
Humans
Radiology, Nuclear Medicine and imaging
Locally advanced breast cancer
breast conservation therapy
skin and connective tissue diseases
business.industry
Micrometastasis
General Medicine
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Radiation therapy
Treatment Outcome
business
neoadjuvant chemotherapy
Subjects
Details
- ISSN :
- 19984138
- Volume :
- 1
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of cancer research and therapeutics
- Accession number :
- edsair.doi.dedup.....1811366e6296acdb95df848847ad8a6e