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Inhibiting Phase Transfer of Protein Nanoparticles by Surface Camouflage–A Versatile and Efficient Protein Encapsulation Strategy
- Source :
- Nano Letters. 21:9458-9467
- Publication Year :
- 2021
- Publisher :
- American Chemical Society (ACS), 2021.
-
Abstract
- Engineering a system with a high mass fraction of active ingredients, especially water-soluble proteins, is still an ongoing challenge. In this work, we developed a versatile surface camouflage strategy that can engineer systems with an ultrahigh mass fraction of proteins. By formulating protein molecules into nanoparticles, the demand of molecular modification was transformed into a surface camouflage of protein nanoparticles. Thanks to electrostatic attractions and van der Waals interactions, we camouflaged the surface of protein nanoparticles through the adsorption of carrier materials. The adsorption of carrier materials successfully inhibited the phase transfer of insulin, albumin, β-lactoglobulin, and ovalbumin nanoparticles. As a result, the obtained microcomposites featured with a record of protein encapsulation efficiencies near 100% and a record of protein mass fraction of 77%. After the encapsulation in microcomposites, the insulin revealed a hypoglycemic effect for at least 14 d with one single injection, while that of insulin solution was only ∼4 h.
- Subjects :
- protein encapsulation
high drug loading
Nanoparticle
Bioengineering
02 engineering and technology
010402 general chemistry
01 natural sciences
symbols.namesake
chemistry.chemical_compound
Adsorption
Phase (matter)
Molecular modification
Insulin
General Materials Science
phase transfer inhibition
biology
Mechanical Engineering
Proteins
surface camouflage
General Chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
Controlled release
0104 chemical sciences
Ovalbumin
chemistry
Chemical engineering
317 Pharmacy
symbols
biology.protein
Nanoparticles
van der Waals force
controlled release
0210 nano-technology
Mass fraction
Subjects
Details
- ISSN :
- 15306992 and 15306984
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Nano Letters
- Accession number :
- edsair.doi.dedup.....1813158c824b91d6ec0eb54dca128b18