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HLA association in MOG-IgG- and AQP4-IgG-related disorders of the CNS in the Dutch population
- Source :
- Neurology(R) neuroimmunology & neuroinflammation, 7. Lippincott Williams & Wilkins, Neurology® Neuroimmunology & Neuroinflammation
- Publication Year :
- 2020
-
Abstract
- ObjectiveTo investigate the possible human leukocyte antigen (HLA) association of both myelin oligodendrocyte glycoprotein (MOG-IgG)-associated diseases (MOGAD) and aquaporin-4 antibody (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSDs) in the Dutch population with European ancestry to clarify similarities or differences in the immunogenetic background of both diseases.MethodsBlood samples from patients in the Dutch national MS/NMOSD expert clinic were tested for MOG-IgG and AQP4-IgG using a cell-based assay. HLA Class I and II genotyping was performed in 43 MOG-IgG–seropositive and 42 AQP4-IgG–seropositive Dutch patients with European ancestry and compared with those of 5,604 Dutch healthy blood donors.ResultsNo significant HLA association was found in MOG-IgG–seropositive patients. The AQP4-IgG–seropositive patients had a significant higher frequency of HLA-A*01 (61.9% vs 33.7%, OR 3.16, 95% CI, 1.707–5.863, p after correction [pc] = 0.0045), HLA-B*08 (61.9% vs 25.6%, OR 4.66, 95% CI, 2.513–8.643, pc < 0.0001), and HLA-DRB1*03 (51.2% vs 27.6%, OR 2.75, 95% CI, 1.495–5.042, pc = 0.0199) compared with controls.ConclusionsThe present study demonstrates differences in the immunogenetic background of MOGAD and AQP4-IgG–positive NMOSD. The strong positive association with HLA-A*01, -B*08, and -DRB1*03 is suggestive of a role of this haplotype in the etiology of AQP4-IgG–positive NMOSD in patients with European ancestry, whereas in MOGAD no evidence was found for any HLA association in these disorders.
- Subjects :
- Adult
Male
0301 basic medicine
Adolescent
Demyelinating Autoimmune Diseases, CNS
Human leukocyte antigen
White People
Article
Myelin oligodendrocyte glycoprotein
Young Adult
03 medical and health sciences
0302 clinical medicine
HLA Antigens
Humans
Medicine
Child
Genotyping
Netherlands
Aquaporin 4
biology
business.industry
Neuromyelitis Optica
Haplotype
Middle Aged
Hla association
030104 developmental biology
Neurology
Child, Preschool
Immunology
Dutch Population
biology.protein
Etiology
Female
Myelin-Oligodendrocyte Glycoprotein
Neurology (clinical)
Antibody
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 23327812
- Database :
- OpenAIRE
- Journal :
- Neurology(R) neuroimmunology & neuroinflammation, 7. Lippincott Williams & Wilkins, Neurology® Neuroimmunology & Neuroinflammation
- Accession number :
- edsair.doi.dedup.....18263a62e3b320b282f5ff9ed88983fc