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Measurement of Sunscreen Immune Protection Factors in Humans: A Consensus Paper
- Source :
- Journal of Investigative Dermatology. 125:403-409
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- It is increasingly accepted that sunscreens should protect against ultraviolet radiation (UVR)-induced immunosuppression, with an index of protection that can be compared with the sun protection factor (SPF). Five groups of immunoprotection researchers met to discuss the status of immune protection factor (IPF) evaluation in human skin in vivo. Current methods rely on a suncreen's inhibition of UVR-induced local suppression of the contact hypersensitivity (CHS) response or the delayed-type hypersensitivity (DTH) response, using either the induction or the elicitation arms of these responses. The induction arm of the CHS response has the advantage of being sensitive to a single sub-erythemal exposure of solar-simulating radiation (SSR) that allows a direct comparison with the SPF. This approach, which necessitates sensitization, requires a large number of volunteers and is too labor intensive and time consuming to become a routine method. The elicitation arm of the CHS or DTH responses exploits prior sensitization to contact or recall antigens and has the advantage of being possible to apply on small groups of volunteers. Some current protocols, however, require repeat SSR exposures, which invalidates a direct comparison with SPF that is based on a single exposure. There is a need for a new simpler method of IPF that will have to be validated against existing models.
- Subjects :
- ultraviolet radiation
medicine.medical_specialty
Skin Neoplasms
Ultraviolet Rays
medicine.medical_treatment
Dermatology
Dermatitis, Contact
Biochemistry
Sun protection factor
Antigen
Immune Tolerance
sunscreens
medicine
Humans
Immunologic Factors
Hypersensitivity, Delayed
Molecular Biology
Ultraviolet radiation
Sensitization
immune protection
Single exposure
integumentary system
Immune protection
business.industry
consensus paper
Contact hypersensitivity
Immunosuppression
Cell Biology
Surgery
medicine.anatomical_structure
Immune System
Immunology
Immunologic Techniques
Sunlight
business
Sunscreening Agents
Subjects
Details
- ISSN :
- 0022202X
- Volume :
- 125
- Database :
- OpenAIRE
- Journal :
- Journal of Investigative Dermatology
- Accession number :
- edsair.doi.dedup.....18372e39c22e351222c30bd5b8a4c40e