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Hindered nucleoside analogs as antiflaviviridae agents
- Source :
- Scopus-Elsevier, Università degli studi di Ferrara-IRIS
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Abstract
- Flaviviridae are an important family of viruses, responsible for widely spread diseases such as dengue and West Nile fever and hepatitis C. Despite the severity of the related diseases, no effective antiviral treatments for infection are available. Following our discovery of adenosine-hindered analogs as potent antiflaviviridae agents, we have continued our investigation on guanosine and inosine derivatives, which were evaluated for activity against BVDV, YFV, DENV, and WNV viruses in cell-based assays. The present study allowed us to identify some newer features that led to improve the antiviral potency (down to the µM range) and to selectively inhibit BVDV and YFV viruses. The molecular modeling results were consistent with the hypothesis that test analogs act as RNA-dependent RNA polymerase (RdRp) inhibitors by interacting with a surface allosteric binding pocket.
- Subjects :
- Hepatitis
biology
Nucleoside analogue
Chemistry
viruses
General Chemical Engineering
Allosteric regulation
Guanosine
General Chemistry
medicine.disease
biology.organism_classification
Virology
Dengue fever
chemistry.chemical_compound
Flaviviridae
Biochemistry
RNA polymerase
medicine
Inosine
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier, Università degli studi di Ferrara-IRIS
- Accession number :
- edsair.doi.dedup.....1842bcd0b16a962ddbfd747741f120d1