Additional file 1 of Effect of low-to-moderate hyperoxia on lung injury in preclinical animal models: a systematic review and meta-analysis

Additional file 1: Figure S1. Flow diagram for the literature search. Figure S2. Effects of FiO2 ≤ 0.60 and > O.21 (FiO2 ≤ 0.60/ > O.21) (upper panel) or FiO2 ≥ 0.60 (lower panel) vs. FiO2s = 0.21 (controls) on the odds ratios of survival (95%CIs) (OR) in studies [author (y)] that also administered an infectious or noninfectious inflammatory challenge in animals. These were studies that included more than one regimen of oxygen or dose of an inflammatory challenge and these groups are shown individually here. Animal type, increased FiO2 level and duration, inflammatory challenge route and type employed and the numbers of surviving and total animals challenged in oxygen or control groups are shown. Open circles show ORs for groups within studies and solid circles show the overall OR for a study when groups could be pooled (I2 level of significance, p ≥ 0.10). These pooled ORs were then employed for overall analysis (Fig. 1). IP intraperitoneal, CLP cecal ligation and puncture, IT intratracheal, L. p. Legionella pneumoniae, LPS lipopolysaccharide, LD low dose, HD high dose. Table S1. Animal numbers for O2 + nonO2 inflammatory challenge studies. Table S2. Results of lung injury measures reported in O2 + nonO2 inflammatory challenge studies for groups exposed to FiO2s≤0.60 and >0.21 or FiO2=0.21. Table 3. Results of lung injury and immune response measures reported in O2 + nonO2 inflammatory challenge studies for groups exposed to FiO2 >0.60 or FiO2=0.21. Table S4. Results of immune response measures reported in O2 + nonO2 inflammatory challenge studies for groups exposed to FiO2s≤0.60 and >0.21. Table S5. Animal numbers for O2 only studies. Table S6. Body weights following oxygen exposure for O2 only studies. Table S7. Results of lung injury measures reported in O2 only studies for groups exposed to FiO2s≤0.60 and >0.21 or FiO2=0.21. Table S8. Results of immune response measures reported in O2 only studies for groups exposed to FiO2s≤0.60 and >0.21 or=0.21. Table S9. Results of lung injury and immune response measures reported in O2 only studies for groups exposed to FiO2s>0.60 or FiO2=0.21. Table S10. Quality of evidence, adapted from SYRCLE.