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Critical Analysis of Non-Thermal Plasma-Driven Modulation of Immune Cells from Clinical Perspective
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 21, Iss 6226, p 6226 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI, 2020.
-
Abstract
- The emerged field of non-thermal plasma (NTP) shows great potential in the alteration of cell redox status, which can be utilized as a promising therapeutic implication. In recent years, the NTP field considerably progresses in the modulation of immune cell function leading to promising in vivo results. In fact, understanding the underlying cellular mechanisms triggered by NTP remains incomplete. In order to boost the field closer to real-life clinical applications, there is a need for a critical overview of the current state-of-the-art. In this review, we conduct a critical analysis of the NTP-triggered modulation of immune cells. Importantly, we analyze pitfalls in the field and identify persisting challenges. We show that the identification of misconceptions opens a door to the development of a research strategy to overcome these limitations. Finally, we propose the idea that solving problems highlighted in this review will accelerate the clinical translation of NTP-based treatments.
- Subjects :
- 0301 basic medicine
Plasma Gases
Computer science
non-thermal plasma
viruses
Immune Cell Function
Review
immunomodulation
Catalysis
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
0302 clinical medicine
Immune system
Humans
cell signaling
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
Immunity, Cellular
Organic Chemistry
Perspective (graphical)
General Medicine
Redox status
Computer Science Applications
030104 developmental biology
Gene Expression Regulation
lcsh:Biology (General)
lcsh:QD1-999
030220 oncology & carcinogenesis
cytotoxicity
Neuroscience
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 21
- Issue :
- 17
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....188cae3b52c5b09064361cc1a2d3e2bd