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Risk Assessment for Highly Pathogenic Avian Influenza A(H5N6/H5N8) Clade 2.3.4.4 Viruses
- Source :
- Emerging Infectious Diseases, Vol 27, Iss 10, Pp 2619-2627 (2021), Emerging Infectious Diseases
- Publication Year :
- 2021
- Publisher :
- Centers for Disease Control and Prevention (CDC), 2021.
-
Abstract
- The numerous global outbreaks and continuous reassortments of highly pathogenic avian influenza (HPAI) A(H5N6/H5N8) clade 2.3.4.4 viruses in birds pose a major risk to the public health. We investigated the tropism and innate host responses of 5 recent HPAI A(H5N6/H5N8) avian isolates of clades 2.3.4.4b, e, and h in human airway organoids and primary human alveolar epithelial cells. The HPAI A(H5N6/H5N8) avian isolates replicated productively but with lower competence than the influenza A(H1N1)pdm09, HPAI A(H5N1), and HPAI A(H5N6) isolates from humans in both or either models. They showed differential cellular tropism in human airway organoids; some infected all 4 major epithelial cell types: ciliated cells, club cells, goblet cells, and basal cells. Our results suggest zoonotic potential but low transmissibility of the HPAI A(H5N6/H5N8) avian isolates among humans. These viruses induced low levels of proinflammatory cytokines/chemokines, which are unlikely to contribute to the pathogenesis of severe disease.
- Subjects :
- Microbiology (medical)
China
Chemokine
Epidemiology
animal diseases
viruses
Infectious and parasitic diseases
RC109-216
medicine.disease_cause
alveolar epithelial cells
human airway organoids
Proinflammatory cytokine
Birds
Risk Assessment for Highly Pathogenic Avian Influenza A(H5N6/H5N8) Clade 2.3.4.4 Viruses
Influenza A Virus, H1N1 Subtype
Influenza, Human
medicine
Animals
Humans
Influenza A Virus, H5N8 Subtype
Clade
Tropism
clade 2.3.4.4
HPAI H5Nx
Influenza A Virus, H5N1 Subtype
biology
Host (biology)
Research
tropism
innate host responses
risk assessment
virus diseases
Outbreak
Virology
Influenza A virus subtype H5N1
Infectious Diseases
Influenza in Birds
biology.protein
Hong Kong
Medicine
influenza
Cellular Tropism
Subjects
Details
- ISSN :
- 10806059 and 10806040
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Emerging Infectious Diseases
- Accession number :
- edsair.doi.dedup.....188e6218c3fea7bb36cc7778fd3b25bc