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Prognostic significance of long non coding maternally expressed gene 3 in pediatric acute myeloid leukemia
- Source :
- Medicine
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- The purpose of this study was to evaluate the correlation of long non-coding RNA maternally expressed gene 3 (Lnc-MEG3) with disease features, treatment response, and survival in pediatric acute myeloid leukemia (AML) patients. Among 92 de novo pediatric AML patients (before treatment and after 1 course of induction) and 40 controls, bone marrow mononuclear cells were obtained. Then, Lnc-MEG3 expression was determined by reverse transcription quantitative polymerase chain reaction. After 1 course of standard induction therapy of pediatric AML patients, complete remission (CR) was assessed. Furthermore, event-free survival (EFS) and overall survival (OS) were determined according to follow-up data. Lnc-MEG3 was reduced in pediatric AML patients compared with controls. In pediatric AML patients, Lnc-MEG3 was correlated with French-American-Britain subtypes and lower Chinese Medical Association risk stratification, while it was not associated with cytogenetic features, FLT3-ITD mutation, CEBPA mutation, NPM1 mutation, WT1 mutation, or National Comprehensive Cancer Network risk stratification. After 1 course of treatment, Lnc-MEG3 exhibited an up-regulation trend. Furthermore, Lnc-MEG3 was of no difference before treatment between patients with and without CR, while elevated Lnc-MEG3 and change of Lnc-MEG3 after 1 course of treatment were associated with increased CR rate. Additionally, increased Lnc-MEG3 expression before treatment was associated with longer EFS but not OS, while enhanced Lnc-MEG3 expression after 1 course of treatment was correlated with both prolonged EFS and OS. Lnc-MEG3 may have clinical significance as a biomarker for assisting with disease management, treatment optimization, and prognosis improvement in pediatric AML patients.
- Subjects :
- Male
Oncology
medicine.medical_specialty
complete remission
Observational Study
risk stratification
Disease
survival
Internal medicine
CEBPA
Biomarkers, Tumor
medicine
Humans
Clinical significance
Child
business.industry
Remission Induction
pediatric acute myeloid leukemia
Cancer
General Medicine
Prognosis
medicine.disease
Reverse transcriptase
Real-time polymerase chain reaction
medicine.anatomical_structure
Leukemia, Myeloid
Child, Preschool
Biomarker (medicine)
Female
RNA, Long Noncoding
Bone marrow
long non-coding RNA maternally expressed gene 3
business
Nucleophosmin
Research Article
Subjects
Details
- ISSN :
- 15365964 and 00257974
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....1891d365839119169b3f49343ffae543