Back to Search
Start Over
Impact of Transcatheter Tricuspid Valve Repair for Severe Tricuspid Regurgitation on Kidney and Liver Function
- Source :
- JACC: Cardiovascular Interventions. 12:1413-1420
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Objectives This study sought to determine the impact of transcatheter tricuspid edge-to-edge valve repair (TTVR) of severe tricuspid regurgitation (TR) on kidney and liver functions. Background TR leads to impairment in renal and hepatic function, which is associated with worse prognosis. TTVR emerged as a treatment option for patients ineligible for cardiac surgery. However, no study has assessed the impact of TTVR on kidney and liver functions. Methods All patients treated with TTVR in our center between March 2016 and June 2018 were included. Kidney and liver functions were compared at baseline, 30 days, and 6 months. Results Over the study period, 126 patients were treated for TR (59 isolated TTVR and 67 TMTVR). Among them, 110 (87.3%) survived at 6 months. Among survivors, renal function remained stable, including among patients with moderate-to-severe chronic kidney disease (mean glomerular filtration rate 37.5 ml/min/1.73 m2 at baseline vs. 40.1 ml/min/1.73 m2 at 6 months; p = 0.39). Regarding liver function, a significant improvement at 6 months was only observed in the alanine transaminase level in the entire cohort (30.7 U/l vs. 24.9 U/l; p Conclusions TR reduction by TTVR is associated with an improvement in liver function, mainly among patients with abnormal liver function at baseline, whereas kidney function remained stable. Accordingly, TTVR is an attractive option especially for patients presenting with severe TR and liver dysfunctions, who are at even higher surgical risk compared with patients who still have normal organ functions.
- Subjects :
- Male
Cardiac Catheterization
medicine.medical_specialty
Time Factors
Renal function
Regurgitation (circulation)
030204 cardiovascular system & hematology
Kidney
Severity of Illness Index
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
030212 general & internal medicine
Renal Insufficiency, Chronic
TRICUSPID VALVE REPAIR
Aged
Aged, 80 and over
Heart Valve Prosthesis Implantation
business.industry
Liver Diseases
Hemodynamics
Recovery of Function
medicine.disease
Tricuspid Valve Insufficiency
Cardiac surgery
Treatment Outcome
medicine.anatomical_structure
Liver
Heart Valve Prosthesis
Cohort
Cardiology
Female
Tricuspid Valve
Liver function
Cardiology and Cardiovascular Medicine
business
Biomarkers
Glomerular Filtration Rate
Kidney disease
Subjects
Details
- ISSN :
- 19368798
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- JACC: Cardiovascular Interventions
- Accession number :
- edsair.doi.dedup.....1899ab5154f6746c7b55c96d419fd537