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Ventricular Septation and Outflow Tract Development in Crocodilians Result in Two Aortas with Bicuspid Semilunar Valves
- Source :
- Journal of Cardiovascular Development and Disease, Volume 8, Issue 10, Journal of Cardiovascular Development and Disease, 8(10). MDPI, Journal of Cardiovascular Development and Disease, Vol 8, Iss 132, p 132 (2021), Journal of cardiovascular development and disease, 8(10). MDPI AG
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Background: The outflow tract of crocodilians resembles that of birds and mammals as ventricular septation is complete. The arterial anatomy, however, presents with a pulmonary trunk originating from the right ventricular cavum, and two aortas originating from either the right or left ventricular cavity. Mixing of blood in crocodilians cannot occur at the ventricular level as in other reptiles but instead takes place at the aortic root level by a shunt, the foramen of Panizza, the opening of which is guarded by two facing semilunar leaflets of both bicuspid aortic valves. Methods: Developmental stages of Alligator mississipiensis, Crocodilus niloticus and Caiman latirostris were studied histologically. Results and Conclusions: The outflow tract septation complex can be divided into two components. The aorto-pulmonary septum divides the pulmonary trunk from both aortas, whereas the interaortic septum divides the systemic from the visceral aorta. Neural crest cells are most likely involved in the formation of both components. Remodeling of the endocardial cushions and both septa results in the formation of bicuspid valves in all three arterial trunks. The foramen of Panizza originates intracardially as a channel in the septal endocardial cushion.
- Subjects :
- pharyngeal arch arteries
congenital, hereditary, and neonatal diseases and abnormalities
semilunar valves
left aorta
Article
Bicuspid valve
medicine.artery
Diseases of the circulatory (Cardiovascular) system
Medicine
Pulmonary Trunk
Pharmacology (medical)
cardiovascular diseases
endocardial cushions
General Pharmacology, Toxicology and Pharmaceutics
Semilunar valves
outflow tract
cartilage
Aorta
Foramen of Panizza
business.industry
Neural crest
pulmonary trunk
Anatomy
right aorta
Shunt (medical)
Coronary arteries
cell_developmental_biology
medicine.anatomical_structure
RC666-701
cardiovascular system
foramen of Panizza
Outflow
business
coronary arteries
Subjects
Details
- Language :
- English
- ISSN :
- 23083425
- Volume :
- 8
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiovascular Development and Disease
- Accession number :
- edsair.doi.dedup.....189aa2c7bd4a4cf3c2d0a5317c50e82b