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Antibody-modified DNase I micelles specifically recognize the neutrophil extracellular traps (NETs) and promote their degradation

Authors :
Nina Filipczak
Xiang Li
Gaurav Rajan Saawant
Satya Siva Kishan Yalamarty
Ed Luther
Vladimir P. Torchilin
Source :
Journal of Controlled Release. 354:109-119
Publication Year :
2023
Publisher :
Elsevier BV, 2023.

Abstract

Neutrophil extracellular traps (NETs) are structures consisting of decondensed chromatin with associated proteins, including histones and antimicrobial peptides, released from activated neutrophils. They are believed to be one of the body's first lines of defense against infectious agents. Despite their beneficial effect on the immune response process, some studies indicate that their excessive formation and the associated accumulation of extracellular DNA (eDNA) together with other polyelectrolytes (F-actin) plays an important role in the pathogenesis of many diseases. Thus NETs formation and removal are clinically significant. The monoclonal antibody 2C5 has strong specificity for intact nucleohistones (NS) and targets NS in NETs as we previously confirmed. Creation of a nano preparation that can specifically recognize and destroy NETs represents the aim for treatment many diseases. 2C5 antibody functionalized micelles coated with DNase I were created to achieve this aim.

Subjects

Subjects :
Pharmaceutical Science

Details

ISSN :
01683659
Volume :
354
Database :
OpenAIRE
Journal :
Journal of Controlled Release
Accession number :
edsair.doi.dedup.....18a430bbe34ffc13b457190634abb9a8
Full Text :
https://doi.org/10.1016/j.jconrel.2022.12.062