Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives

Authors :: Paulo Gonzalez
Cristina Theoduloz
Guillermo Schmeda-Hirschmann
Mariano Walter Pertino
María M. Afonso
J. A. Palenzuela
Daniel Droguett
Erdem Yesilada
Francisco Monsalve
Source :: Molecules, Molecules, Vol 16, Iss 10, Pp 8614-8628 (2011), MOLECULES, Artículos CONICYT, CONICYT Chile, instacron:CONICYT, Volume 16, Issue 10, Pages 8614-8628
Publication Year :: 2011
Publisher :: MDPI AG, 2011.
Abstract: New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells.