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Nervous system diseases are associated with the severity and mortality of patients with COVID-19: a systematic review and meta-analysis
- Source :
- Epidemiology and Infection
- Publication Year :
- 2021
- Publisher :
- Cambridge University Press (CUP), 2021.
-
Abstract
- Coronavirus disease 2019 (COVID-19) has become a global pandemic. Previous studies showed that comorbidities in patients with COVID-19 are risk factors for adverse outcomes. This study aimed to clarify the association between nervous system diseases and severity or mortality in patients with COVID-19. We performed a systematic literature search of four electronic databases and included studies reporting the prevalence of nervous system diseases in COVID-19 patients with severe and non-severe disease or among survivors and non-survivors. The included studies were pooled into a meta-analysis to calculate the odds ratio (OR) with 95% confidence intervals (95%CI). We included 69 studies involving 17 879 patients. The nervous system diseases were associated with COVID-19 severity (OR = 3.19, 95%CI: 2.37 to 4.30, P < 0.001) and mortality (OR = 3.75, 95%CI: 2.68 to 5.25, P < 0.001). Specifically, compared with the patients without cerebrovascular disease, patients with cerebrovascular disease infected with COVID-19 had a higher risk of severity (OR = 3.10, 95%CI: 2.21 to 4.36, P < 0.001) and mortality (OR = 3.45, 95% CI: 2.46 to 4.84, P < 0.001). Stroke was associated with severe COVID-19 disease (OR = 1.95, 95%CI: 1.11 to 3.42, P = 0.020). No significant differences were found for the prevalence of epilepsy (OR = 1.00, 95%CI: 0.42 to 2.35, P = 0.994) and dementia (OR = 2.39, 95%CI: 0.55 to 10.48, P = 0.247) between non-severe and severe COVID-19 patients. There was no significant association between stroke (OR = 1.79, 95%CI: 0.76 to 4.23, P = 0.185), epilepsy (OR = 2.08, 95%CI: 0.08 to 50.91, P = 0.654) and COVID-19 mortality. In conclusion, nervous system diseases and cerebrovascular disease were associated with severity and mortality of patients with COVID-19. There might be confounding factors that influence the relationship between nervous system diseases and COVID-19 severity as well as mortality.
- Subjects :
- medicine.medical_specialty
Epidemiology
Disease
Comorbidity
Review
Severity of Illness Index
03 medical and health sciences
0302 clinical medicine
Nervous system disease
Internal medicine
Severity of illness
Odds Ratio
Medicine
Humans
030212 general & internal medicine
Cerebrovascular disease
Stroke
Epilepsy
business.industry
SARS-CoV-2
severe illness
COVID-19
Odds ratio
medicine.disease
mortality
meta-analysis
Cerebrovascular Disorders
Infectious Diseases
Meta-analysis
nervous system disease
Dementia
Nervous System Diseases
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 14694409 and 09502688
- Database :
- OpenAIRE
- Journal :
- Epidemiology and Infection
- Accession number :
- edsair.doi.dedup.....18c8e6c5bf308d29b7d0772db63a55ae
- Full Text :
- https://doi.org/10.1017/s0950268821000376