Telomerase and Chromosome End Protection In Vivo: the TPP1 Connection

In an article published in this issue of Developmental Cell , Maria Blasco's group shows that the telomere end-binding protein TPP1 is involved in both end protection and telomerase regulation in vivo. Importantly, they highlight the relevance of telomerase activity in highly proliferative tissues and in reprogramming of cells to induced pluripotency (iPS).