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Neuroprotective schinortriterpenoids with diverse scaffolds from Schisandra henryi
- Source :
- Bioorganic chemistry. 105
- Publication Year :
- 2020
-
Abstract
- Eleven undescribed schinortriterpenoids (SNTs) and one known analogue (12) were isolated from the stems and leaves of Schisandra henryi. Their diverse structures included preschisanartane (1), 18-norschiartane (2-5, 12), schiartane (6 and 7), and schisanartane (8-11) skeletons, which were elucidated by comprehensive NMR, MS, electronic circular dichroism analyses, single crystal X-ray diffraction and biogenetic considerations. 1 was the first case of preschisanartane-type SNT with six-membered lactone ring, and 2 was one of the most highly oxygenated 18-norschiartane SNTs. Three types of the highly oxygenated SNTs, 1, 4, 10 and 11, effectively prevent apoptosis induced by corticosterone in PC12 cells. In addition, 11 showed neurite outgrowth-promoting activity.
- Subjects :
- Circular dichroism
Neurite
Stereochemistry
Drug Evaluation, Preclinical
Ring (chemistry)
01 natural sciences
Biochemistry
Neuroprotection
PC12 Cells
Schisandra henryi
Lactones
Drug Discovery
Animals
Humans
Schiartane
Molecular Biology
Schisandra
chemistry.chemical_classification
Molecular Structure
Plant Stems
010405 organic chemistry
Plant Extracts
Organic Chemistry
Triterpenes
0104 chemical sciences
Rats
Oxygen
Plant Leaves
010404 medicinal & biomolecular chemistry
Neuroprotective Agents
chemistry
Corticosterone
Single crystal
Lactone
Subjects
Details
- ISSN :
- 10902120
- Volume :
- 105
- Database :
- OpenAIRE
- Journal :
- Bioorganic chemistry
- Accession number :
- edsair.doi.dedup.....190ae8b6e0510458f4d08d9cfc4d7950