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Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase activities in early stages of development in dystrophic chickens
- Source :
- Journal of the Neurological Sciences. 68:47-60
- Publication Year :
- 1985
- Publisher :
- Elsevier BV, 1985.
-
Abstract
- Glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconate dehydrogenase (6PGDH) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activities were assayed in superficial pectoral muscles of hereditary dystrophic chickens, 1 week, 2 weeks, 4 weeks and 4 months after hatching. In control chickens, activities of G6PDH and 6PGDH were very low at 4 months of age; however, at 1 week of age, they were much higher than those at 4 months of age. Activities of G6PDH and 6PGDH were significantly higher in dystrophic chickens compared with those in the controls at all the stages of development studied. These findings suggest that considerable activities of G6PDH and 6PGDH are present within the pectoral muscle cells at early stages of development, at least in dystrophic chickens. GAPDH activity was significantly lower in dystrophic chickens at 2 weeks, 4 weeks and 4 months of age compared with those in control chickens. These findings together with our previous studies (Mizuno 1984a,b) in which increased activities of superoxide dismutases, catalase, glutathione peroxidase and glutathione reductase were reported in dystrophic chickens, indicate the presence of an increased capacity for the turnover of oxygen-free radicals within muscle cells in dystrophic chickens, and that oxygen-free radicals and the related activated oxygen species may be playing a role in inducing cellular damage.
- Subjects :
- medicine.medical_specialty
animal structures
Glutathione reductase
Dehydrogenase
Glucosephosphate Dehydrogenase
Biology
Pectoralis Muscles
Superoxide dismutase
chemistry.chemical_compound
Internal medicine
medicine
Animals
Glucose-6-phosphate dehydrogenase
Phosphogluconate dehydrogenase
Glyceraldehyde 3-phosphate dehydrogenase
chemistry.chemical_classification
Phosphogluconate Dehydrogenase
Glutathione peroxidase
Age Factors
Glyceraldehyde-3-Phosphate Dehydrogenases
Muscular Dystrophy, Animal
Kinetics
Endocrinology
Neurology
chemistry
Catalase
biology.protein
Neurology (clinical)
Chickens
Subjects
Details
- ISSN :
- 0022510X
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Journal of the Neurological Sciences
- Accession number :
- edsair.doi.dedup.....191330cd9045dcdf6f7bf1135facdab6
- Full Text :
- https://doi.org/10.1016/0022-510x(85)90049-8