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Bone marrow cell characteristics associated with patient profile and cardiac performance outcomes in the LateTIME-Cardiovascular Cell Therapy Research Network (CCTRN) trial
- Source :
- American heart journal. 179
- Publication Year :
- 2015
-
Abstract
- Background Although several preclinical studies have shown that bone marrow cell (BMC) transplantation promotes cardiac recovery after myocardial infarction, clinical trials with unfractionated bone marrow have shown variable improvements in cardiac function. Methods To determine whether in a population of post–myocardial infarction patients, functional recovery after BM transplant is associated with specific BMC subpopulation, we examined the association between BMCs with left ventricular (LV) function in the LateTIME-CCTRN trial. Results In this population, we found that older individuals had higher numbers of BM CD133 + and CD3 + cells. Bone marrow from individuals with high body mass index had lower CD45 dim /CD11b dim levels, whereas those with hypertension and higher C-reactive protein levels had higher numbers of CD133 + cells. Smoking was associated with higher levels of CD133 + /CD34 + /VEGFR2 + cells and lower levels of CD3 + cells. Adjusted multivariate analysis indicated that CD11b dim cells were negatively associated with changes in LV ejection fraction and wall motion in both the infarct and border zones. Change in LV ejection fraction was positively associated with CD133 + , CD34 + , and CD45 + /CXCR4 dim cells as well as faster BMC growth rates in endothelial colony forming assays. Conclusions In the LateTIME population, BM composition varied with patient characteristics and treatment. Irrespective of cell therapy, recovery of LV function was greater in patients with greater BM abundance of CD133 + and CD34 + cells and worse in those with higher levels of CD11b dim cells. Bone marrow phenotype might predict clinical response before BMC therapy and administration of selected BM constituents could potentially improve outcomes of other future clinical trials.
- Subjects :
- 0301 basic medicine
Male
Pathology
CD34
Myocardial Infarction
Antigens, CD34
030204 cardiovascular system & hematology
Ventricular Function, Left
Body Mass Index
Cell therapy
Cohort Studies
Ventricular Dysfunction, Left
0302 clinical medicine
Myocardial infarction
AC133 Antigen
Prospective Studies
Bone Marrow Transplantation
education.field_of_study
Ejection fraction
CD11b Antigen
Smoking
Middle Aged
Magnetic Resonance Imaging
medicine.anatomical_structure
C-Reactive Protein
Hypertension
Cardiology
Female
Cardiology and Cardiovascular Medicine
Cardiac function curve
Adult
medicine.medical_specialty
Receptors, CXCR4
Population
Bone Marrow Cells
Article
03 medical and health sciences
Internal medicine
medicine
Humans
Obesity
education
Aged
business.industry
Recovery of Function
medicine.disease
Transplantation
030104 developmental biology
Leukocyte Common Antigens
Bone marrow
business
Subjects
Details
- ISSN :
- 10976744
- Volume :
- 179
- Database :
- OpenAIRE
- Journal :
- American heart journal
- Accession number :
- edsair.doi.dedup.....1923b586a182fb591840ed237de2b473