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Sympathetic regulation of vascular tone via noradrenaline and serotonin in the rat carotid body as revealed by intracellular calcium imaging
- Source :
- Brain research. 1596
- Publication Year :
- 2014
-
Abstract
- Hypoxia-induced chemosensory activity in the carotid body (CB) may be enhanced by the sympathetic regulation of vascular tone in the CB. In the present study, we recorded cervical sympathetic nerve activity in rats exposed to hypoxia, and examined noradrenaline (NA)- and serotonin (5-HT)-induced intracellular Ca(2+) ([Ca(2+)]i) responses in smooth muscle cells and pericytes in isolated blood vessels from the CB. Multifiber electrical activity recorded from the cervical sympathetic trunk was increased during the inhalation of hypoxic gas. NA induced [Ca(2+)]i increases in smooth muscle cells in arteriole specimens, whereas 5-HT did not cause any [Ca(2+)]i responses. However, NA did not induce [Ca(2+)]i increases in pericytes in capillaries, whereas 5-HT did and this response was inhibited by the 5-HT2 receptor antagonist, ketanserin. In conclusion, cervical sympathetic nerves enhanced by hypoxia may reduce blood flow in the CB in order to increase chemosensitivity. Thus, hypoxic chemosensitivity in the CB may involve a positive feedback mechanism via sympathetic nerves.
- Subjects :
- Male
medicine.medical_specialty
Serotonin
Ketanserin
Sympathetic Nervous System
medicine.drug_class
Synaptophysin
Dopamine beta-Hydroxylase
Biology
Tryptophan Hydroxylase
Calcium in biology
Norepinephrine
Arteriole
Internal medicine
medicine.artery
medicine
Animals
Antigens
Rats, Wistar
Hypoxia
Molecular Biology
Carotid Body
General Neuroscience
Muscle, Smooth
Blood flow
Hypoxia (medical)
Receptor antagonist
Actins
Rats
Endocrinology
medicine.anatomical_structure
Blood Vessels
Carotid body
Calcium
Proteoglycans
Neurology (clinical)
Serotonin Antagonists
medicine.symptom
Developmental Biology
medicine.drug
Subjects
Details
- ISSN :
- 18726240
- Volume :
- 1596
- Database :
- OpenAIRE
- Journal :
- Brain research
- Accession number :
- edsair.doi.dedup.....192e598cf840717cc1546deabd828367