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The Yersinia pestis GTPase BipA Promotes Pathogenesis of Primary Pneumonic Plague
- Source :
- Infection and Immunity
- Publication Year :
- 2021
- Publisher :
- American Society for Microbiology, 2021.
-
Abstract
- Yersinia pestis is a highly virulent pathogen and the causative agent of bubonic, septicemic, and pneumonic plague. Primary pneumonic plague caused by inhalation of respiratory droplets contaminated with Y. pestis is nearly 100% lethal within 4 to 7 days without antibiotic intervention.<br />Yersinia pestis is a highly virulent pathogen and the causative agent of bubonic, septicemic, and pneumonic plague. Primary pneumonic plague caused by inhalation of respiratory droplets contaminated with Y. pestis is nearly 100% lethal within 4 to 7 days without antibiotic intervention. Pneumonic plague progresses in two phases, beginning with extensive bacterial replication in the lung with minimal host responsiveness, followed by the abrupt onset of a lethal proinflammatory response. The precise mechanisms by which Y. pestis is able to colonize the lung and survive two very distinct disease phases remain largely unknown. To date, a few bacterial virulence factors, including the Ysc type 3 secretion system, are known to contribute to the pathogenesis of primary pneumonic plague. The bacterial GTPase BipA has been shown to regulate expression of virulence factors in a number of Gram-negative bacteria, including Pseudomonas aeruginosa, Escherichia coli, and Salmonella enterica serovar Typhi. However, the role of BipA in Y. pestis has yet to be investigated. Here, we show that BipA is a Y. pestis virulence factor that promotes defense against early neutrophil-mediated bacterial killing in the lung. This work identifies a novel Y. pestis virulence factor and highlights the importance of early bacterial/neutrophil interactions in the lung during primary pneumonic plague.
- Subjects :
- Pneumonic plague
Virulence Factors
Yersinia pestis
Immunology
Virulence
Yersinia
medicine.disease_cause
Microbiology
Bubonic plague
Virulence factor
GTP Phosphohydrolases
Mice
Bacterial Proteins
medicine
Animals
Humans
Pathogen
Plague
biology
Pseudomonas aeruginosa
pathogenesis
medicine.disease
biology.organism_classification
Molecular Pathogenesis
Mice, Inbred C57BL
Disease Models, Animal
Infectious Diseases
Models, Animal
Female
Parasitology
pneumonic plague
bacterial GTPases
Subjects
Details
- ISSN :
- 10985522 and 00199567
- Volume :
- 89
- Database :
- OpenAIRE
- Journal :
- Infection and Immunity
- Accession number :
- edsair.doi.dedup.....196011f6571094cb698d79aaf104a717