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Simultaneous determination of cytosine arabinoside and its metabolite uracil arabinoside in human plasma by LC-MS/MS: Application to pharmacokinetics-pharmacogenetics pilot study in AML patients
- Source :
- Journal of Chromatography B Biomedical Sciences and Applications, Journal of Chromatography B Biomedical Sciences and Applications, Elsevier, 2019, 1126-1127, pp.121770. ⟨10.1016/j.jchromb.2019.121770⟩, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, Elsevier, 2019, 1126-1127, pp.121770. ⟨10.1016/j.jchromb.2019.121770⟩, Journal of Chromatography B Biomedical Sciences and Applications, 2019, 1126-1127, pp.121770. ⟨10.1016/j.jchromb.2019.121770⟩
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- International audience; Purine analogs like aracytine (AraC) are a mainstay for treating acute myeloid leukemia (AML). There are marked differences in drug dosing and scheduling depending on the protocols when treating AML patients with AraC. Large inter-patient pharmacokinetics variability has been reported, and genetic polymorphisms affecting cytidine deaminase (CDA), the liver enzyme responsible for the conversion of Ara-C to inactive uracil arabinoside (AraU) could be a culprit for either life-threatening toxicities or poor efficacy related to substantial changes in plasma exposure levels among patients. The quantitative determination of Ara-C in plasma is challenging due the required sensitivity because of the short half-life of this drug (i.e.
- Subjects :
- Metabolite
[SDV]Life Sciences [q-bio]
Clinical Biochemistry
Pilot Projects
MESH: Arabinofuranosyluracil
Pharmacology
030226 pharmacology & pharmacy
01 natural sciences
Biochemistry
Analytical Chemistry
MESH: Linear Models
chemistry.chemical_compound
0302 clinical medicine
Tandem Mass Spectrometry
MESH: Drug Monitoring
MESH: Cytarabine
ComputingMilieux_MISCELLANEOUS
Chromatography, High Pressure Liquid
media_common
MESH: Antimetabolites, Antineoplastic
Chemistry
Cytarabine
Myeloid leukemia
General Medicine
Cytidine deaminase
3. Good health
MESH: Reproducibility of Results
Leukemia, Myeloid, Acute
Drug Monitoring
MESH: Leukemia, Myeloid, Acute
medicine.drug
Drug
Antimetabolites, Antineoplastic
media_common.quotation_subject
Purine analogue
Acute myeloid leukemia patients
[SDV.CAN]Life Sciences [q-bio]/Cancer
Sensitivity and Specificity
03 medical and health sciences
Pharmacokinetics
medicine
Humans
LC-MS/MS
MESH: Chromatography, High Pressure Liquid
Chromatography
MESH: Humans
010401 analytical chemistry
Arabinofuranosyluracil
Reproducibility of Results
MESH: Tandem Mass Spectrometry
Cell Biology
MESH: Pilot Projects
MESH: Sensitivity and Specificity
0104 chemical sciences
Linear Models
Pharmacogenetics
Subjects
Details
- Language :
- English
- ISSN :
- 03784347, 15700232, and 1873376X
- Database :
- OpenAIRE
- Journal :
- Journal of Chromatography B Biomedical Sciences and Applications, Journal of Chromatography B Biomedical Sciences and Applications, Elsevier, 2019, 1126-1127, pp.121770. ⟨10.1016/j.jchromb.2019.121770⟩, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, Elsevier, 2019, 1126-1127, pp.121770. ⟨10.1016/j.jchromb.2019.121770⟩, Journal of Chromatography B Biomedical Sciences and Applications, 2019, 1126-1127, pp.121770. ⟨10.1016/j.jchromb.2019.121770⟩
- Accession number :
- edsair.doi.dedup.....197713233e52e8e17267586de653535b
- Full Text :
- https://doi.org/10.1016/j.jchromb.2019.121770⟩