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Lumpfish ( Cyclopterus lumpus, Linnaeus) is susceptible to viral nervous necrosis: Result of an experimental infection with different genotypes of Betanodavirus
- Source :
- Toffan, A, De Salvador, M, Scholz, F, Pretto, T, Buratin, A, Rodger, H D, Toson, M, Cuenca, A & Vendramin, N 2019, ' Lumpfish ( Cyclopterus lumpus, Linnaeus) is susceptible to viral nervous necrosis: Result of an experimental infection with different genotypes of Betanodavirus ', Journal of Fish Diseases, vol. 42, no. 12, pp. 1667-1676 . https://doi.org/10.1111/jfd.13088
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- In recent years, the use of cleaner fish for biological control of sea lice has increased considerably. Along with this, a number of infectious diseases have emerged. The aim of this study was to investigate the susceptibility of lumpfish (Cyclopterus lumpus) to Betanodavirus since it was detected in asymptomatic wild wrasses in Norway and Sweden. Three betanodaviruses were used to challenge lumpfish: one RGNNV genotype and two BFNNV genotypes. Fish were injected and monitored for 4 weeks. Brain samples from clinically affected specimens, from weekly randomly selected fish and survivors were subjected to molecular testing, viral isolation, histopathology and immunohistochemistry. Reduced survival was observed but was attributed to tail-biting behaviour, since no nervous signs were observed throughout the study. Betanodavirus RNA was detected in all samples, additionally suggesting an active replication of the virus in the brain. Viral isolation confirmed molecular biology results and revealed a high viral titre in BFNNV-infected groups associated with typical lesions in brains and eyes of survivor fish. We concluded that lumpfish are susceptible to Betanodavirus, as proven by the high viral titre and brain lesions detected, but further studies are necessary to understand if Betanodavirus can cause clinical disease in this species.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Necrosis
Genotype
Veterinary (miscellaneous)
Cyclopterus lumpus
Betanodavirus
Aquatic Science
Cleaner fish
Virus
Fish Diseases
03 medical and health sciences
RNA Virus Infections
SDG 3 - Good Health and Well-being
medicine
Animals
Nodaviridae
14. Life underwater
biology
Norway
04 agricultural and veterinary sciences
biology.organism_classification
Virology
Perciformes
3. Good health
030104 developmental biology
Lumpfish
040102 fisheries
0401 agriculture, forestry, and fisheries
Nervous necrosis virus
Histopathology
Disease Susceptibility
medicine.symptom
Viral load
Viral encephalopathy and retinopathy
Subjects
Details
- ISSN :
- 13652761 and 01407775
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Journal of Fish Diseases
- Accession number :
- edsair.doi.dedup.....197f313b54a34b5c772da9030472c308