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minibrain: A new protein kinase family involved in postembryonic neurogenesis in Drosophila
- Source :
- Neuron. (2):287-301
-
Abstract
- The development of the adult central nervous system of Drosophila requires a precise and reproducible pattern of neuroblast proliferation during postembryonic neurogenesis. We show here that mutations in the minibrain (mnb) gene cause an abnormal spacing of neuroblasts in the outer proliferation center (opc) of larval brain, with the implication that mnb opc neuroblasts produce less neuronal progeny than do wild type. As a consequence, the adult mnb brain exhibits a specific and marked size reduction of the optic lobes and central brain hemispheres. The insufficient number of distinct neurons in mnb brains is correlated with specific abnormalities in visual and olfactory behavior. The mnb gene encodes a novel, cell type-specific serine-threonine protein kinase family that is expressed and required in distinct neuroblast proliferation centers during postembryonic neurogenesis. The mnb kinases share extensive sequence similarities with kinases involved in the regulation of cell division.
- Subjects :
- DYRK1B
DNA, Complementary
Embryo, Nonmammalian
DYRK1A
Neuroscience(all)
Molecular Sequence Data
Restriction Mapping
Central nervous system
Gene Expression
Genes, Insect
Protein Serine-Threonine Kinases
Biology
Nervous System
Polymerase Chain Reaction
DYRK1A Gene
Mice
Neuroblast
medicine
Animals
Drosophila Proteins
Humans
Amino Acid Sequence
Protein kinase A
DNA Primers
Neuroblast proliferation
Base Sequence
Sequence Homology, Amino Acid
General Neuroscience
Neurogenesis
fungi
Protein-Tyrosine Kinases
Ganglia, Invertebrate
Drosophila melanogaster
medicine.anatomical_structure
nervous system
Protein Kinases
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 08966273
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Neuron
- Accession number :
- edsair.doi.dedup.....19893432f6544f659483813d428ef07c
- Full Text :
- https://doi.org/10.1016/0896-6273(95)90286-4